The comparative effect and safety of 2 IU compared with 4 IU/m2/day of recombinant human growth hormone (rhGH) was studied in 38 growth hormone deficient children regarding the impact of several factors on short term (one year) and long term (three year) growth response. In 21 newly diagnosed patients, three years of rhGH treatment resulted in a significant increase of height velocity SD score,...

Background and Aims: Environmental and genetic factors play a role in the pathogenesis and natural history of non-alcoholic steatohepatitis (NASH). The aim of this study was to determine if the G-238A (allele TNFA) and G-308A (allele TNF2) tumor necrosis factor-alpha (TNF) and Ala9Val manganese superoxide dismutase (MnSOD) polymorphisms were associated with NASH in a case-control study of subje...

RESEARCH DESIGN AND METHODSdOne-thousand two-hundred sixty-four individuals without known diabetes in the Diabetes Community Lifestyle Improvement Program in Chennai, India, had a 75-g oral glucose tolerance test, with glucose and insulinmeasured at 0, 30, and 120min. Type 2 diabetes, isolated impaired fasting glucose (iIFG), isolated impaired glucose tolerance (iIGT), combined impaired fasting...

background: ncds are the leading disease burdens in china and the ncds risk factors shifts have accelerated at an unprecedented scale over the past 30 years. the aim of this study was to analysis the natural trajectories of ncds risk factors over the life course. methods: the large-scale longitudinal data from the chns includes nine rounds of surveys between 1989 and 2011. overall, 145913 obser...

During a period of four years between June, IS, 1988 to June, IS, 1992 one hundred and fourteen patients with congestive heart failure (CHF) were admitted to the pediatric department of Taleghani General Hospital. During the above period, 192 patients with heart disease were hospitalized at this department and CHF was the cause of admission in 59.4% of them. Congenital heart disease (CHO) w...

AIM The aim of the study is to assess the differences between clinical scales of MMPI-2 among women and men suffering from depressive disorders. METHOD 36 patients were examined (aged 23-62 years, average age = 51.27, SD = 8.84): 19 women (52.77%, aged 23-59, average age = 51.16, SD = 4.74) and 17 men (47.23%, aged: 23-61, average age = 51.41, SD = 12.07). All patients were hospitalised in th...

OBJECTIVE The prevalence of obesity is increasing in many European countries and in the United States. This report examines the mortality and morbidity associated with being overweight and obese in the Caerphilly Prospective Study and the relative effects of weight in middle age and self reported weight at 18 years. DESIGN All men aged 45 to 59 years from the town of Caerphilly, South Wales a...

BACKGROUND The main associations of body-mass index (BMI) with overall and cause-specific mortality can best be assessed by long-term prospective follow-up of large numbers of people. The Prospective Studies Collaboration aimed to investigate these associations by sharing data from many studies. METHODS Collaborative analyses were undertaken of baseline BMI versus mortality in 57 prospective ...

Few longitudinal studies have been carried out to investigate the cognitive decline in early onset of familial Alzheimer's disease (FAD). In this study 12 patients with FAD (M age = 49.61 years, SD = 4.99), 10 patients with sporadic Alzheimer's disease (SAD) (M age = 71.40, SD =10.00), and 15 matched normal controls (M age = 45.01, SD = 7.24) were selected. A comprehensive neuropsychological ba...

The growth pattern of 66 patients (50 males, 16 females) with isolated gonadotrophin deficiency (IGnD), who had reached their final height with epiphyseal closure, was evaluated. For the purpose of analysis the males were divided into two groups according to age at referral: group 1 <16 years (n=23) and group 2 ,16 years (n=27). Sex hormone treatment was initiated at a mean (SD) chronological a...