Due to the inability of classical chemotherapeutic agents to exclusively target tumor cells, these treatments are associated with severe toxicity profiles. Thus, long-circulating liposomes have been developed in the past to enhance accumulation in tumor tissue by passive targeting. Accordingly, commercially available liposomal formulations of sterically stabilized liposomal doxorubicin (Caelyx,...

The aim of this study was to compare the production of nanocrystals of a poorly watersoluble antioxidant, quercetin, by top-down and bottom-up techniques. The top-down method used was high pressure homogenization (HPH) and bottom-up method of evaporative precipitation of nanosuspension (EPN) was used and the products from both these methods were compared. The particle size of the original drug ...

Various technological approaches are widely used to prepare drug nanocarriers in order to protect the active substances from the unfavourable impact of the environment (hydrolysis, enzymatic degradation, etc.) and to improve the dissolution and bioavailability. Conventional methods like grinding, spray drying, polymerization, coacervation, lyophilisation etc., are extensively used but they have...

The efficient extraction of phenols from grapes is an important step for their reliable quantification. aim was to optimise the lyophilisation process and grape skins seeds. phenol yield lyophilised tissues investigated with different accelerated solvent (ASE) operating conditions. Skins seeds were separated frozen berries without being ground. weight loss during followed daily. Phenols extract...

This study aimed at determining the proximate, functional, and physicochemical properties of Basella alba whole flour (BWF) protein concentrate (BPC) for use as food ingredients with a view to improve their utilization by producing from its content which will serve cheap but abundant source protein. OAU farm provided fresh leaves. The stalk was quickly cut off, leaves were cleaned under running...

About 20 per cent of the live weight freshwater fish is visceral mass a rich source protein, lipids, polyunsaturated fatty acids, soluble vitamins, phospholipids etc having very great agro industrial products. Any scientific technique that uses strong squanders coming about because harvesting by recuperating biomolecules like lipids and proteins brings extra income as well helps to reduce dumpi...

The circular bioeconomy for the production of high-value products has gained attention due to new policies reuse and sustainable valorisation locally available underutilised raw material in several countries. This study is focused explore potential by-products winemaking through direct dehydration processes. phenolic composition (anthocyanins uncolored phenols) their quantitative pattern skin, ...

Metabolomics is a technique that allows for the evaluation of entire extractable chemical profile plant, example, using high-resolution mass spectrometry (HRMS) and can be used to evaluate plant stress responses, such as those due drought. Metabolomic analysis dependent upon efficiency extraction protocol. Currently, there are two common procedures widely in metabolomic experiments, extract fro...

Polyelectrolyte complexes (PEC) consisting of an alginate core entrapping the protein ovalbumin and the chitosan coating were prepared by the self-assembly of oppositely charged polyelectrolytes. The PEC were prepared at pH 4.0 and consisted of alginate, ovalbumin and chitosan in a concentration of 0.5, 0.5 and 0.05 mg/ml, respectively, having a particle size of around 300nm, a zeta potential o...