background: cd4+ and cd8+ t cells are the main types of lymphocytes in cell-mediated immunity and play a central role in the induction of efficient immune responses against tumors. the frequencies of t cell subtypes in the peripheral blood and tumor tissues, and draining lymph nodes (dln) can be considered as useful markers for evaluation of the immune system in cancers. methods: in this study,...

background helicobacter pylori is responsible for one of the most common human infections and is a major risk factor for stomach ulcer disease and gastric cancer. h. pylori infection has been reported to be associated with generation and development of coronary artery disease (cad). moreover, diabetic patients positive for h. pylori infection showed a higher prevalence of cad compared to h. pyl...

background helicobacter pylori (h. pylori) is recognized as the causative agent of peptic and duodenal ulcers, gastric adenocarcinoma, and low-grade mucosa-associated lymphoid tissue (malt) lymphoma . in the present study, we investigate the genotoxic damage of lysates of h. pylori in human b lymphocytes. materials and methodsâ  human b lymphocytes were treated with 0, 10, 20, and 30 âµg/ l of ...

background: celiac disease (cd) is a small bowel enteropathy caused by permanent wheat gluten intolerance. one of the earliest signs of the mucosal immune activation in cd is an increase in the intestinal intraepithelial lymphocytes (iiels) count in the small intestinal epithelium. although most of those iiels express ??tcr, cd is characterized by an increase in the gdtcr + iiels. objective: th...

conclusions the changes of treg and th17 cells and their associated cytokines were related to virological and biochemical responses. results in complete and partial-responders, treg cells frequencies and il-10, tgf-β1, il-23 levels were all decreased significantly after na therapy, while th17 cells and the il-17 levels were increased slightly. treg/th17 ratio was only dramatically declined in c...

perforin gene (prf1) mutations have been reported in 20-30% of patients with familial hemophagocytic lymphohistiocytosis (fhl), an immune disorder of infancy and early childhood. cytotoxic t and natural killer (nk) cell activities are remarkably reduced or ab-sent in fhl patients. we report the first cases of familial hemophagocytic lymphohistiocy-tosis in an iranian family with two siblings. e...

background: human peripheral blood nk cells constitutively express cd56 and cd16 antigens. peripheral blood nk cells seem to be strongly related with decidual nk cells, and may reflect the decidual nk cell functional status. there are varied reports concerning the relationship between nk cell cytotoxicity in women with recurrent spontaneous abortion. objective: to study nk activity in women wit...

application of nuclear magnetic resonance imaging (nmri) as a non-invasive and accurate imaging procedure has been widely used in recent years. meanwhile, the biological effects of magnetic fields of several tesla (t) and high energy radiofrequency (rf) is not fully known yet. because of controversy over this issue, the present research has been carried out in order to verify the effects of mag...

conclusions as l. crispatus and l. jensenni were significantly higher in bv infected women and the cytotoxic effect of l. crispatus on tumoral cervical cells was high, introduction of new probiotics seems necessary. results l. crispatus, l. gasseri, l. iners, l. jensenii, l. acidophilus and l. rhamnosus were the most frequently occurring species in vagina of healthy iranian women. l. crispatus ...