Background: Azathioprine is an immunosuppressive agent that is used in a variety of dermatologic, digestive and hematologic disorders in both humans and small animals. Aims: The effects of long term Azathioprine administration on complete blood count, rate of CD4+ and CD8+ lymphocytes, serum immunoglobulins and protein concentrations of mixed-breed dogs were evaluated in this study. Methods: 24...

Rabbit anti-guinea pig lymphocyte serum is an efficient stimulus of the synthesis of DNA by guinea pig lymph node cells in vitro. The ability of ALS to stimulate lymphocytes is characterized by its lack of dependence on prior sensitization, the magnitude of the response it elicits, and the stimulation of all sensitive lymph node cells simultaneously within a very narrow range of ALS concentrati...

Submit Manuscript | http://medcraveonline.com Abbreviations: AMP: Adenosine Monophosphate; ATP: Adenosine Triphosphate; cAMP: Cyclic Adenosine Monophosphate; CD: Cluster of Differentiation; CTLA-4: Cytotoxic T-LymphocyteAssociated Protein 4; IDO: Indoleamine 2,3-dioxygenase; IFN: Interferon; IL: Interleukin; LAG3: Lymphocyte-Activation Gene 3; TCR: T Cell Receptor; TGF-β: Transforming Growth Fa...

Electrophoresis of urine to evaluate different urinary proteins has been used in recent years veterinary medicine, as it can be a useful laboratory tool the early detection kidney damage. However, capillary electrophoresis (UCE) not reported healthy cats. In dogs, reference intervals have established and compared with pathological samples these provide an easily interpretable pattern. The elect...

[email protected] Abbreviations ABMR: Antibody Mediated Rejections; ADMSC: Adipose Tissue Derived Mesenchymal Stem Cells; AHG: Anti-Human Globulin; ASHI: American Society of Histocompatibility and Immunogenetics; CGN: Chronic Glomerulonephritis; CNI: Calcineurin Inhibitor; CRF: Chronic Renal Failure; DMEM: Dulbecco’s Modified Eagle’s Medium; DSA: Donor Specific Antibody; DST: Donor Specifi...

Abstract Background Axial spondyloarthritis (axial SpA) is a chronic inflammatory disorder could lead to disability due the failure of timely treatment. The role lymphocyte-to-monocyte ratio (LMR) in axial SpA remains unclear. aim this study was investigate LMR diagnosis, disease activity classification and sacroiliitis staging. Methods Seventy-eight patients [51males 27 females; mean age 41.0 ...

An experimental analysis of the factors responsible for the observed differences in the course of virus-induced papillomas of the rabbit has shown that some are referable to the virus, others to the cells, and yet others to host influences. The interplay of these factors affords enlightening illustration of the nature of the cell-virus relationship in virus-induced tumors. Retrogression of the ...

This article summarises the current knowledge of the rabbit coccidia and the disease they cause. Various aspects, such as life cycles, localisation in the host, pathology and pathogenicity, immunity and control, are discussed.

OBJECTIVE The aim of this study was to investigate the success rate and effects on survival of different anti-thymocyte globulin (ATG) preparations in patients diagnosed with aplastic anemia. SUBJECTS AND METHODS Of the total 24 patients included in the study, 12 were male and 12 female with a median age of 44 years (range 16-72). Nine patients received Lymphoglobulin®, 7 Thymoglobulin® and A...

Ipilimumab is a human monoclonal IgG1 antibody against CTLA-4 that has been shown to prolong the overall survival of advanced melanoma. The most common adverse events associated with ipilimumab are immune-related. Severe hematological toxicity is rare. We report a case of severe neutropenia following ipilimumab therapy that fully resolved after the administration of prednisone, cyclosporine, an...