نتایج جستجو برای: lymphoblastic

تعداد نتایج: 35386  

Journal: :journal of medical signals and sensors 0
morteza moradi amin saeed kermani ardeshir talebi

acute lymphoblastic leukemia is the most common form of pediatric cancer which is categorized into three l1, l2, and l3 and could bedetected through screening of blood and bone marrow smears by pathologists. due to being time‑consuming and tediousness of theprocedure, a computer‑based system is acquired for convenient detection of acute lymphoblastic leukemia. microscopic images areacquired fro...

Fatemeh Malek, Navid Zavvar, Shiva Nazari,

Acute leukemia which is the most common cancer in children is a heterogeneous group of clonal malignancies. The conversion of the leukemic cell lineage during the course of the disease or later is termed lineage switch. It has been rarely reported in the literature. In leukemia lineage switch, conversions from lymphoblastic leukemia to myeloid leukemia or vice versa are reported. Herein, we rep...

Journal: :Haematologica 2011
Vera Grossmann Wolfgang Kern Stefan Harbich Tamara Alpermann Sabine Jeromin Susanne Schnittger Claudia Haferlach Torsten Haferlach Alexander Kohlmann

The runt-related transcription factor 1, RUNX1, is crucial in the development of myeloid and lymphoid cell lineages and has been reported to be mutated in myeloid malignancies in approximately 30% of cases. In this study, the mutational status of RUNX1 was investigated in 128 acute lymphoblastic leukemia patients. We detected a mutation rate of 18.3% (13 of 71) in patients with T-cell acute lym...

Journal: :Haematologica 2013
Denise Niewerth Niels E Franke Gerrit Jansen Yehuda G Assaraf Johan van Meerloo Christopher J Kirk Jeremiah Degenhardt Janet Anderl Aaron D Schimmer Sonja Zweegman Valerie de Haas Terzah M Horton Gertjan J L Kaspers Jacqueline Cloos

The ex vivo sensitivity of pediatric leukemia cells to the proteasome inhibitor bortezomib was compared to 3 next generation proteasome inhibitors: the epoxyketone-based irreversible proteasome inhibitors carfilzomib, its orally bio-available analog ONX 0912, and the immunoproteasome inhibitor ONX 0914. LC50 values were determined by MTT cytotoxicity assays for 29 childhood acute lymphoblastic ...

2006
Hiroyoshi Sawada Vardaman H. Gilmore Grady F. Saunders

Chromatins prepared from leukemic lymphosarcoma cell(s), (LS), acute lymphoblastic leukemia cells, chronic lymphocytic leukemia cells and normal tissue culture lymphocytes (NC-37) were studied with respect to their chemical compositions, thermal denaturation profiles, and template activities. Acute lymphoblastic leukemia and LS chromatins had approximately 2 to 4 times the nonhistone protein an...

Journal: :Haematologica 2010
Xiang-shan Fan Sa A Wang

The 2008 World Health Organization (WHO) classification of tumors of hematopoietic and lymphoid tissues introduced a new category for myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB or FGFR1. Many of these cases present as a myeloproliferative neoplasm, usually with eosinophilia. However, neoplasms associated with rearrangement of PDGFRA can present as acute...

Journal: :Cancer research 1973
H Sawada V H Gilmore G F Saunders

Chromatins prepared from leukemic lymphosarcoma cell(s), (LS), acute lymphoblastic leukemia cells, chronic lymphocytic leukemia cells and normal tissue culture lymphocytes (NC-37) were studied with respect to their chemical compositions, thermal denaturation profiles, and template activities. Acute lymphoblastic leukemia and LS chromatins had approximately 2 to 4 times the nonhistone protein an...

Alemi , Ashraf , Farrokhifar, Majid , Haghi Karamallah , Mojtaba , Zare-Zardini , Hadi ,

Background: Niosomes or Nonionic surfactant vesicles are nano vehicles utilized in drug delivery systems, especially in cancer therapy. In this study, these vesicles were applied as delivery system for anticancer drug, paclitaxel and then, its anticancer activities was compared with free paclitaxel on Human Acute Lymphoblastic Leukemia (ALL) cell line Nalm-6. Materialas and Methods: In this exp...

Journal: :gene, cell and tissue 0
mohammad hashemi cellular and molecular research center, zahedan university of medical sciences, zahedan, ir iran; department of clinical biochemistry, school of medicine, zahedan university of medical sciences, zahedan, ir iran; department of clinical biochemistry, school of medicine, zahedan university of medical sciences, zahedan, ir iran. tel: +98-5413235122 majid naderi genetics of non communicable disease research center, zahedan university of medical sciences, zahedan, ir iran; department of pediatrics, school of medicine, zahedan university of medical sciences, zahedan, ir iran ebrahim eskandari nasab genetics of non communicable disease research center, zahedan university of medical sciences, zahedan, ir iran seyed shahaboddin hasani department of clinical biochemistry, school of medicine, zahedan university of medical sciences, zahedan, ir iran simin sadeghi bojd department of pediatrics, school of medicine, zahedan university of medical sciences, zahedan, ir iran mohsen taheri genetics of non communicable disease research center, zahedan university of medical sciences, zahedan, ir iran

conclusions our findings indicated that mdm2 40-bp ins/del polymorphism was not associated with all in our iranian population. further studies with larger sample sizes and diverse ethnicities are required to verify our findings. background the human murine double minute 2 (mdm2), an oncoprotein, is the major negative regulator of p53. objectives the purpose of this study was to evaluate the imp...

آقا محمدی, اصغر, دیوسالار, کوروس, رامیار, اصغر, صفری, زهرا, عظیمی, سیروس, محمودی, مجید,

Background: Acute lymphoblastic leukemia (ALL) is the most common malignancy in childhood, characterized by excess lymphoblasts, and immature white blood cells that are continuously multiplying and overproducing in the bone marrow. The aim of this investigation was to measure the sensitivity of lymphocytes against gamma irradiation in patients with acute lymphoblastic leukemia, and also find ou...

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