OBJECTIVE The aim of the study was to estimate the radiation-absorbed doses and to study the in vivo and in vitro stability as well as pharmacokinetic characteristics of lutetium-177 (Lu-177) prostate-specific membrane antigen (PSMA)-617. METHODS For this purpose, 7 patients who underwent Lu-177-PSMA therapy were included into the study. The injected Lu-177-PSMA-617 activity ranged from 3.6 t...

BACKGROUND Due to its high expression in prostate cancer, PSMA (prostate-specific membrane antigen) represents an ideal target for both diagnostic imaging and endoradiotherapeutic approaches. Based on a previously published highly specific PSMA ligand ([(68)Ga]DOTA-FFK(Sub-KuE)), we developed a corresponding metabolically stable 1,4,7,10-tetraazacyclododececane,1-(glutaric acid)-4,7,10-triaceti...

PURPOSE To examine the effect of combining angiostatin with photodynamic therapy (PDT) using Lutetium Texaphyrin (Lu-Tex; Alcon, Fort Worth, TX) as a photosensitizer in bovine retinal capillary endothelial (BRCE) and retinal pigment epithelial (RPE) cells and to determine the mode of PDT-induced cell death in these cell lines. METHODS Cultured BRCE and RPE cells were incubated with angiostati...

Cervical cancer caused by the infection with the human papillomavirus (HPV) remains the fourth leading killer of women worldwide. Therefore, more efficacious treatments are needed. We are developing radioimmunotherapy (RIT) of HPV-positive cervical cancers by targeting E6 and E7 viral oncoproteins expressed by the cancer cells with the radiolabeled monoclonal antibodies (mAbs). To investigate t...

Neuroendocrine tumors (NETs) possess unique features including expression of peptide hormone receptors as well as the capacity to concentrate and take up precursor forms of amines and peptides making hormones that are stored in secretory granules within the tumor cells (APUD). The expression of somatostatin receptors on tumor cells have been widely explored during the last two decades starting ...

The authors wish to thank Nathaniel Schenker and Pei-Lu Chiu, whose detailed reviews and comments helped us to make many improvements to this report. In addition, special thanks to Dr. Schenker for permission to borrow text from his report (with Trivellore E. Raghunathan, Pei-Lu Chiu, Diane M. Makuc, Guangyu Zhang, and Alan J. Cohen) on the multiple imputation of family income and personal earn...

UNLABELLED : Lu and Elston have recently proposed a procedure for developing optimal receiver operating characteristic curves that maximize the area under a receiver operating characteristic curve in the setting of a predictive genetic test. The method requires only summary data, not individual level genetic data. In an era of increased data sharing, we investigate the performance of this algor...

Processing of G4 DNA by Dna2 Helicase/Nuclease and RPA Provides Insights into the Mechanism of Dna2/RPA Substrate Recognition Taro Masuda-Sasa, Piotr Polaczek, Xiao P. Peng, Lu Chen and Judith L. Campbell Braun Laboratories, 147-75, California Institute of Technology, Pasadena, CA 91125 Running title: Dna2/RPA/G4 interactions