the aerial parts of salvia glutinosa afforded in addition to lupeol, a - and ? - amyrin a furanosesquiterpene, its structure being established by high field nmr techniques. the relative configuration at c-1, c-10, c-4, c-5 and c-6 of 6?tigloyloxyglechomafuran 1 was determined by the observed noe's

Albizia coriaria stembark is among the most common raw materials used to manufacture herbal products in Uganda. While plant material sourced from wild, there are neither monographs nor chemical analytical methods for its standardisation. In addition, good cultivation, harvesting, and manufacturing practices not mandatory. This leads inconsistent quality of products. work developed TLC HPLC eval...

Purpose: Conventional therapies to treat prostate cancer (CaP) of androgen-dependent phenotype (ADPC) and castration-resistant phenotype (CRPC) are deficient in outcome which has necessitated a need to identify those agents that could target AR for both disease types. We provide mechanism-based evidence that lupeol (Lup-20(29)-en-3b-ol) is a potent inhibitor of androgen receptor (AR) in vitro

Curtisia dentata is used in African traditional medicine to treat variety of infections. C. dentata leaves were collected from Buffelskloof Nature Reserve, South Africa. The ethanol, chloroform, ethyl acetate and acetone extracts were evaluated for antimicrobial activity using micro dilution assay against Escherichia coli, Pseudomonas aeruginosa, Mycobacterium smegmatis, Mycoplasma hominis, Can...

Cancer is one of the most eminent diseases of modern times and numerous natural products derived from medicinal plants have been identified as potential sources of antitumor drugs. A successful anticancer drug must target or inhibit tumor cells whilst causing minimal damage to healthy cells. The present study aimed to investigate the antitumor efficacy of ethyl acetate extract, and other isolat...

Two new compounds: 2-(3',4'-dihydroxyphenyl) ethyl-3-O-α-L-rhamnopyranosyl-4-O-p-hydroxyphenylacetyl-6-O-caffeoyl-β-D-glucopyranoside and 2-(3',4'-dihydroxyphenyl) ethyl-3-O-α-L-rhamnopyranosyl-4-O-piperidine-3-carboxylic acid-6-O-caffeoyl-β-D-glucopyranoside were isolated from the stem bark of Jacaranda mimosaefolia. In addition, the known compounds lupeol, betulinaldehyde, terminic acid, betu...

Four steroids, 5α,8α-epidioxy-(24ξ)-ergosta-6,22-dien-3β-ol (1), β-sitosterol (2), β-sitostenone (3), and stigmastenone (4), along with 10 known compounds were isolated from the whole plants of Leucaena leucocephala (Leguminosae). 1, Lupeol (5), 1,3-dipalmitoyl-2-oleoylglycerol (6), methylparabene (8) and isovanillic acid (9) were found for the first time from the species. The structure of thes...

The ethanolic and acetone extracts of the whole plant of Elephantopus scaber were found to contain ethyl hexadecanoate, ethyl-9,12-octadecadienoate, ethyl-(Z)9-octadecenoate, ethyl octadecanoate, lupeol, stigmasterol, stigmasterol glucoside, deoxyelephantopin (1) and two new germacranolide sesquiterpene lactones named 17,19-dihydrodeoxyelephantopin (2) and iso-17,19-dihydrodeoxyelephantopin (3)...

Isolation of anti-proliferative compounds from plants is always hindered by the complexities plant’s nature and tedious processes. Clinacanthus nutans (Burm. f.) Lindau a medicinal plant with reported activities. Our study aimed to isolate potential present in C. plant. To start with, for our study, we came up strategy first profiling volatile leaf, stem root using GC-MS. Comparing profiles gre...

Development of analytical method on high performance thin layer chromatography for estimation content marker compound, preferably bioactive constituent, in traditional herb has become a rational approach its standardization. The literature does not reveal any report phytochemical investigation to standardize Calotropis gigantea roots the basis compounds. Non-availability such study prompted us ...