Background: Stage IV colorectal cancer (CRC) exhibits heterogeneous characteristics in tumor extent and biology. The overall survival of patients with metastatic CRC has improved the development multimodal treatments new chemotherapeutic drugs.Current Concepts: Resection is performed for liver, lung, or peritoneal metastases. Conversion surgeries to resect oligometastatic lesions have been deve...

BACKGROUND Lung cancer with ovarian metastasis or adnexal metastasis harboring anaplastic lymphoma kinase (ALK) gene translocation is rare. Crizotinib, a novel ALK tyrosine kinase inhibitor, has already shown an impressive single-agent activity in ALK positive lung cancer. METHODS To summarize the case of clinical data and treatment of a 33-year-old woman with pelvic adnexal metastasis NSCLC....

Cancer metastasis is tightly regulated by the interaction of tumor cells and host organ microenvironments. Matrix metalloproteinases (MMPs), produced by both tumor cells and host stromal cells, play a central role in tumor invasion and angiogenesis. We determined whether metastatic potential of lung cancer to multiple organs is dependent solely on the expression of MMPs by tumor cells, using tw...

Lung cancer is the leading cause of cancer-related death worldwide. Epithelial-mesenchymal transition (EMT) promotes lung cancer progression and metastasis, especially in lung adenocarcinoma. Sex determining region Y-box protein 5 (SOX5) is known to stimulate the progression of various cancers. Here, we used immunohistochemical analysis to reveal that SOX5 levels were increased in 90 lung adeno...

Background: Distinguishing synchronous double primary lung adenocarcinoma (SDPLA) from intrapulmonary metastasis (IPM) of cancer has significant therapeutic and prognostic values. This study aimed to develop validate a CT-based radiomics model differentiate SDPLA IPM.

A predilection of metastasis to the lungs has been noted for several types of cancer. Herein, we summarize underlying mechanisms for lung tropism of metastasis. We discuss the identification of a gene signature in primary breast tumors predicting metastasis to the lungs, as well as functional validation of selected genes of the signature. We outline the contribution of pre- and metastatic niche...

abstract   soft tissue sarcomas of the oral cavity are uncommon malignancies those of smooth-muscle origin are extremely rare. leiomyosarcomas of the tongue are very rare. either surgery or radiation therapy with or without chemotherapy are the treatment modalities which improve prognosis. we are presenting a 32-year-old man with leiomyosarcoma of the lateral aspect of the oral tongue with neck...

Lung cancer represents the foremost cause of cancer-related mortality in both men and women throughout the world. Metastasis to the brain constitutes a major problem in the management of patients with lung cancer. However, the mechanism of brain-specific metastasis in lung cancer has not been fully elucidated. Chemokines and their receptors have emerged as attractive targets regulating the canc...

BACKGROUND To make the difference between two uncommon entities, small cell prostate carcinoma and prostatic metastasis of small cell lung cancer. METHODS We describe a case of single extrapulmonar metastasis in the prostate from small lung carcinoma. RESULTS We describe a case of single extrapulmonar metastasis in the prostate from small lung carcinoma. CONCLUSIONS Clinical and radiograp...