BACKGROUND There are conflicting data concerning the effect of gastroesophageal reflux disease (GERD) on esophageal motor function. HYPOTHESIS Duration of GERD might affect severity of symptoms, grade of esophageal mucosal injury, and esophageal motor behavior. DESIGN Retrospective study of a defined cohort. SETTINGS Two referral centers, one of them academic, for esophageal gastrointesti...

In the ethiological investigation of dysphagia, a mechanical obstruction in the esophageal tube of benign or a malign origin is almost always observed. However, a motor disorder must be considered in the absence of these findings. Hypertensive lower esophageal sphincter (HLES) is a type of motor disorder characterized by high pressure in the lower esophagus sphincter (LES) presenting a value hi...

BACKGROUND/AIMS In high-resolution manometry lower esophageal sphincter pressure (LESP) is measured relative to intragastric pressure, however Gastric Marker™ (GM) location used to determine resting LESP is not well established with hiatal hernia (HH). We test the hypothesis that measured resting LESP varies with HH based on GM location. METHODS Subjects with HH ≥ 2 cm were included. The eSle...

The aim of this study was to determine the mechanism of initiation of transient upper esophageal sphincter relaxation (TUESR) caused by gastric air distension. Cats (n = 31) were decerebrated, EMG electrodes were placed on the cricopharyngeus, a gastric fistula was formed, and a strain gauge was sewn on the lower esophageal sphincter (n = 8). Injection of air (114 ± 13 ml) in the stomach caused...

The manometry with water-perfused or solid-state catheters is the predominant diagnostic procedure to detect motility disorders of the esophagus. Another method is the manometry using gas-perfused catheters. Although the high-resolution manometry is the method of first choice, the conventional manometry with helium has some advantages: the simple and hygienically unproblematic use and the absen...

Background: Vasoactive intestinal peptide (VIP) is an important neurotransmitter involved in the modulation of gastrointestinal function through stimulation VIP receptors. However, expression VPAC1R, VPAC2R and PAC1R human Lower esophageal sphincter (LES) has not been fully clarified. Therefore, purpose this study to explore these receptors sphincter, responses peptide, role responses.

CONTEXT Barrett's esophagus (BE) is characterized by intestinal metaplasia in the distal esophagus and is classified as short-segment (<3 cm - SSBE) or long-segment (>3 cm - LSSBE). It is suggested that LSSBE is associated with more severe esophageal motor abnormalities and increased acid exposure time than SSBE. OBJECTIVE To evaluate the prevalence of esophageal manometriy abnormalities and ...

BACKGROUND Esophageal motility has been described in the literature as having differences between men and women. Most of these investigations use the water perfusion method for esophageal manometry. In this investigation the esophageal motility of men and women was compared with high-resolution manometry of the esophagus. OBJECTIVE To compare the esophageal motility of men and women with the ...