نتایج جستجو برای: longevity
تعداد نتایج: 18074 فیلتر نتایج به سال:
BACKGROUND Individuals with exceptional longevity and their offspring manifest a lower prevalence of age-related diseases than families without longevity. However, the contribution of dietary habits to protection from disease has not been systematically assessed in families with exceptional longevity. OBJECTIVE The aim of this study is to compare dietary patterns between individuals with pare...
RPD3 histone deacetylase and nutrition have distinct but interacting effects on Drosophila longevity
Single-gene mutations that extend longevity have revealed regulatory pathways related to aging and longevity. RPD3 is a conserved histone deacetylase (Class I HDAC). Previously we showed that Drosophila rpd3 mutations increase longevity. Here we tested the longevity effects of RPD3 on multiple nutrient levels. Dietary restriction (DR) has additive effects on RPD3-mediated longevity extension, b...
BACKGROUND The genetic contribution to longevity in humans has been estimated to range from 15% to 25%. Only two genes, APOE and FOXO3, have shown association with longevity in multiple independent studies. METHODS We conducted a meta-analysis of genome-wide association studies including 6,036 longevity cases, age ≥90 years, and 3,757 controls that died between ages 55 and 80 years. We additi...
OBJECTIVE To determine if individuals who carry mitochondrial markers which have been previously shown to affect longevity also have differential lifetime reproductive success (LRS). METHODS We extracted the mtDNA from living subjects residing in Atenas, Costa Rica. Since mtDNA does not recombine, and its probability of mutation is low, we assume that all maternal ancestors of the living subj...
We have mapped a protein interaction network of human homologs of proteins that modify longevity in invertebrate species. This network is derived from a proteome-scale human protein interaction Core Network generated through unbiased high-throughput yeast two-hybrid searches. The longevity network is composed of 175 human homologs of proteins known to confer increased longevity through loss of ...
The objective of this study was to evaluate non-genetic factors affecting longevity and survival of Guilan sheep from birth to yearling. Longevity and survival records of 41037 lambs born from 496 rams and 10256 ewes of Guilan sheep were analyzed using linear and Weibull models. Results indicated that the overall mean of longevity was 1260.84 days. The fixed effects of flock, dam age, sex, year...
Pricing and risk management for longevity risk has increasingly become a major challenge for life insurers and pension funds around the world. Risk transfer to financial markets, with their major capacity for efficient risk pooling, is an area of significant development for a successful longevity product market. The structuring and pricing of longevity risk using modern securitization methods, ...
The evolution of postmenopausal longevity in human females has been the subject of debate. Specifically, there is disagreement about whether the evolution of the trait should be understood as an adaptive or a neutral process, and if the former, what the selective mechanism is. There are two main adaptive proposals to explain the evolution of postreproductive longevity: the grandmother and the m...
in order to evaluate eight different protein sources in honey bee nutrition, some experiments were conducted as a completely randomized designs with four replicates and three steps incubator, field and overwintering in isfahan region. protein sources were lentil flour, soybean flour, soybean meal, bread yeast, wheat gluten, skim milk powder, fish meal and pollen. results showed that the longevi...
cotton bollworm, helicoverpa armigera (hübner) is one of the most destructive insect pests on many crops in the world that has been found to develop resistance against conventional insecticides. using insecticides with different modes of action may result in appropriate control of the pest and delay insecticide resistance development. in this study, lethal and sublethal effects of emamectin ben...
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