Using the sample of long Gamma-ray bursts (GRBs) detected by Swift-BAT before June 2007, we measure the cumulative distribution of the peak photon fluxes (logN–logP ) of the Swift bursts. Compared with the BATSE sample, we find that the two distributions are consistent after correcting the band pass difference, suggesting that the two instruments are sampling the same population of bursts. We a...

The parameters of lipophilicity of spironolactone (a single member of steroids group), which is widely applied as diuretic and antihypertensive agent, were experimentally determined by reversed-phase TLC and HPLC methods as well as calculated using different computer programs and also by a novel mode based on topological indices. Various stationary phases, such as RP-18WFA4254, RP-2F254, RP-18F...

This work quantifies how persistent increases in processor speed compared to I/O speed reduce the performance gap between specialized, high performance messaging layers and general purpose protocols such as TCP/IP and UDP/IP. The comparison is important because specialized layers sacrifice considerable system connectivity and robustness to obtain increased performance. We first quantify the sca...

Kinematics of 237 Chromospherically Active Binaries (CAB) were studied. The sample is heterogeneous with different orbits and physically different components from F to M spectral type main sequence stars to G and K giants and super giants. The computed U , V , W space velocities indicate the sample is also heterogeneous in the velocity space. That is, both kinematically younger and older system...

the purpose of this work is to develop robust and interpretable quantitative structure”activity relationship (qsar) models for assessing the aquatic toxicity of phenols using a combined set of descriptors encompassing the logp and recently developed variables (monconn-z variables). the used dataset consists of 250 chemicals with toxicity data to the ciliate tetrahymena pyriformis. for each comp...

Quantitative structure–activity relationship (QSAR) models were developed to predict for CCR5 binding affinity of substituted 1-(3, 3-diphenylpropyl)-piperidinyl amides and ureas using multiple linear regression (MLR) and artificial neural network (ANN) techniques. A model with four descriptors, including Hydrogen-bonding donors HBD(R7), the partition coefficient between n-octanol and water log...

The antibacterial activity of some substituted benzimidazole derivatives against Gram negative bacteria Escherichia coli was investigated. The tested compounds displayed in vitro inhibitory activity and their minimum inhibitory concentrations were determined. Quantitative structure-activity relationship has been used to study the relationships between the antibacterial activity and lipophilicit...

The empirically calculated parameter LogP(o/w), the log(10) of the coefficient for solvent partitioning between 1-octanol and water, has been used to provide the key data for a unique non-covalent interaction force field called HINT (Hydropathic INTeractions). This experimentally-derived force field encodes entropic as well as enthalpic information and also includes some representation of solva...

In PRAM emulations, universal hashing is a well-known method for distributing the address space among memory modules. However, if the memory access patterns of an application often result in high module congestion, it is necessary to rehash by choosing another hash function and redistributing data on the fly. For the case of linear hash functions h(x) = axmodm we present an algorithm to rehash ...

The ALOGPS 2.1 was developed to predict 1-octanol/water partition coefficients, logP, and aqueous solubility of neutral compounds. An exclusive feature of this program is its ability to incorporate new user-provided data by means of self-learning properties of Associative Neural Networks. Using this feature, it calculated a similar performance, RMSE = 0.7 and mean average error 0.5, for 2569 ne...