Respiration, activity of oleate oxidation and composition of the total fatty acids of rat liver were investigated in 3’-Me-DAB feeding. 1. Oxidative phosphorylation of rat liver mitochondria decreased temporarily at relatively earlier stages (about 2 to 3 weeks) in 3’-Me-DAB feeding. 2. The activity of oleate oxidation of rat liver mitochondria decreased rapidly to about one third of that in co...

King AL, Swain TM, Dickinson DA, Lesort MJ, Bailey SM. Chronic ethanol consumption enhances sensitivity to Ca -mediated opening of the mitochondrial permeability transition pore and increases cyclophilin D in liver. Am J Physiol Gastrointest Liver Physiol 299: G954– G966, 2010. First published July 22, 2010; doi:10.1152/ajpgi.00246.2010.— Chronic ethanol consumption increases mitochondrial oxid...

The article provides information on the effect of pesticides - butylcaptax and droppa respiration oxidative phosphorylation liver mitochondria in rat rats their embryos. It has been shown that reduce oxidation succinate α-ketoglutarate V4*, V3 V dnf states drug conjugation pregnant animals most significant inhibition ADF formation respiratory chain fatal maternal occurs via NAD-dependent pathwa...

Malonyl-CoA inhibits the carnitine-dependent transport of activated fatty acids into mitochondria by inhibiting the outer carnitine palmitoyltransferase (McGarry et al., 1978). Recent studies in several laboratories have shown that malonyl-CoA is not an ordinary competitive inhibitor of the enzyme. Liver mitochondria from fasted or diabetic rats are less inhibited by malonyl-CoA than are mitoch...

The generation of 14CO2 from [1-14C]lysine by hepatic mitochondria through the saccharopine pathway is controlled by intramitochondrial concentrations of lysine, 2-oxoglutarate and NADPH. Mitochondria, isolated from rats pre-treated with glucagon, exhibited higher activities of L-lysine: 2-oxoglutarate reductase, saccharopine dehydrogenase and 2-aminoadipate aminotransferase. The flux through t...

Detailed studies correlating changes in mitochondrial optical density, packed volume, and ultrastructure associated with osmotically-induced swelling were performed. Various swelling states were established by incubating mitochondria (isolated in 0.25 M sucrose) at 0 degrees C for 5 min in series of KCl and sucrose solutions ranging in tonicity from 250 to 3 milliosmols. Reversibility of swelli...

Previous studies demonstrated that CSE induces oxidative stress and its consequences on isolated mitochondria obtained from lung, heart and brain which may provide insight into the role of CSE in human health and disease. The present study was carried out to further characterize and compare toxic effect of CSE extract on isolated mitochondria obtained from either a directly contacting tissue (i...

L-[U-W]Leucine incorporation into the trichloroacetic acid-precipitable fraction of mitochondria after incubation with succinate as energy source was significantly higher with normal rat liver mitochondria than with hypophysectomized rat liver mitochondria. The incorporation was sensitive to inhibition by chloramphenicol, terramycin, dinitrophenol, and NaCN, but not to RNase and cycloheximide. ...