Based on the principal clinical and pathological features, autoimmune diseases can be broadly divided into localized (involving only a single organ or tissue) and systemic (involving multiple organs). The liver is a lymphoid organ that not only participates in the immune response, but also a target of autoimmune reactions. Autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and primary ...

conclusions use of ha in an algorithm model, is an extra and valuable tool for assessing liver necro inflammatory injuries- in parallel with liver biopsy- but more comprehensive studies are needed to approve the use of ha as an appropriate clinical tool. results there are several scientific studies indicating ha as a biomarker for high score fibrosis and cirrhosis in various liver diseases alon...

conclusions the apri had the highest sensitivity and specificity (64% and 71%, respectively) for prediction of the presence of liver disease. we suggest that apri may be applicable for the detection of a severe liver disease. objectives in this study, we evaluated and compared several available indices of the severity of liver diseases in patients with hepatitis. patients and methods exclusion ...

Liver diseases related to pregnancy may be associated with preeclampsia (liver dysfunction related to preeclampsia; hemolysis, elevated liver enzymes, and low platelets with or without preeclampsia [HELLP syndrome]; and acute fatty liver of pregnancy) or may not involve preeclampsia (hyperemesis gravidarum and intrahepatic cholestasis of pregnancy). Liver diseases associated with pregnancy have...

Nonalcoholic steatohepatitis NASH) is a reasonably well-defined clinicopathological entity; it has been reported more commonly in women than in men or children of both sexes and it appears to be most closely associated with obesity, diabetes mellitus and related abnormalities, such as hyperlipidaemia and hyperglycaemia. However, the association with female gender3 obesity and diabetes may not b...

Chemerin is a chemoattractant protein and moreover has a role in adipogenesis, angiogenesis and glucose homeostasis. Chemerin is primarily synthesized and secreted by adipocytes and hepatocytes. Chemerin receptors chemokine-like receptor 1 (CMKLR1), G-protein coupled receptor 1 (GPR1) and CC-motif chemokine receptorlike 2 (CCRL2) are all expressed in the liver suggesting that chemerin may be re...

The liver is essential for copper metabolism. Copper metabolism is highly conserved between different species. This article provides the reader with an overview of copper storage disorders in humans and animals. Diagnosis and treatment of copper-associated hepatitis are described, and breed-specific characteristics of the disease are explained. A literature review references publications about ...

Background: Chronic liver diseases whatever their etiologies could be associated with immunological disturbances. Objectives: Our aim was to evaluate the prevalence and characteristics of autoimmune chronic diseases. Methods: We performed a retrospective analysis data from consecutive patients followed in our department for recruited January 2010 December 2019. Demographic, clinical, paraclinic...

Polycystic liver diseases (PCLDs) are genetic disorders with heterogeneous etiologies and a range of phenotypic presentations. PCLD exhibits both autosomal or recessive dominant pattern of inheritance and is characterized by the progressive development of multiple cysts, isolated or associated with polycystic kidney disease, that appear more extensive in women. Cholangiocytes have primary cilia...

To date, the knowledge on the natural history of HCV infection and the risk factors associated with progression of liver disease in children is limited. Progressive liver disease, including hepatocellular carcinoma, is rare but has been reported (1). Early effective treatment can prevent potential hepatic complications in later life. The association of Peg-IFN plus ribavirin is the option of ch...