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Much ground has been gained in recent years in improving treatments for people with bipolar disorder. These exciting developments are long overdue. As recently as 1993, only one medication, lithium, was approved for the treatment of this severe, recurrent illness. Psychotherapeutic strategies had been either neglected or abandoned. Several factors seem to have contributed to this protracted per...

A controlled blind study was carried out to establish the efficacy of Sodium Valproate as the first line of treatment in Acute Mania. Patients were studied over a period of 4 weeks. Using randomised table patients were assigned to either lithium or valproate. Decrease in the psychopathology was evident within 2-3 weeks. Valproate was found to be as effective as Lithium in controlling the manic ...

Objective: To report a case of lithium induced bilateral nonpitting pedal edema. Methods: The clinical data of a bipolar affective disorder patient with current episode of mania and psychotic symptoms who experienced bilateral non pitting pedal edema with lithium. Results: The patient was a 29 yr old female who developed bilateral non-pitting type pedal edema with lithium therapy with normal pl...

BACKGROUND Although a number of studies have assessed the management of mania in routine clinical practice, no studies have so far evaluated the short- and long-term management and outcome of patients affected by bipolar mania in different European countries. The objective of the study is to present, in the context of a large multicenter survey (EMBLEM study), an overview of the baseline data o...

Manic bipolar is diagnosed by psychomotor agitation, increased goal-directed activity, insomnia, grandiosity, excessive speech, and risky behavior. Animal studies aimed to modeling mania are commonly based in psychostimulants-induced hyperlocomotion. The exploration of other behaviors related with mania is mandatory to investigate this phase of bipolar disorder in animals. In this study, the ho...

The mood stabilizer lithium is used successfully in the treatment of bipolar affective disorder. However, treatment compliance is frequently poor and sudden withdrawal from lithium therapy is associated with a significantly increased risk of rebound mania. In this study we have used rodents to identify neurobiological changes in dopamine function occurring during chronic lithium treatment and w...

A 43-year-old woman with bipolar type II disorder and comorbid migraine without aura had experienced recurrent depressive episodes since age 30 (some with complete, spon tan eous recovery) and had taken various classes of antidepressants. During the past 5 years, she had a rapid-cycling course of illness, with depressive episodes of 3 weeks’ duration and a week of hypomanic symptoms each month....

OBJECTIVE Novel antipsychotics are increasingly used in the treatment of bipolar and schizoaffective mania. This paper presents an overview of the controlled studies in this field. METHOD Using cross-references, a computerized search was performed on MEDLINE and EMBASE psychiatry covering the period 1990-2002. RESULTS Olanzapine and risperidone, added to mood stabilizers, and olanzapine as ...

OBJECTIVE To compare the effects of topiramate versus valproate sodium as an add-on therapy to a combination of lithium and risperidone (Li+Ris) on body weight and serum lipid profile in children and adolescents with bipolar disorder. METHODS In a single-blind randomized clinical trial, thirty children and adolescents with bipolar disorder type I in the manic or mixed phase, treated with the ...