OBJECTIVES The aim of this study was to evaluate the association of sex hormones with anthropometry in a large population-based cohort, with liquid chromatography-mass spectrometry (LCMS)-based sex hormone measurements and imaging markers. STUDY DESIGN/MAIN OUTCOME MEASURES Cross-sectional data from 957 men and women from the population-based Study of Health in Pomerania (SHIP) were used. Ass...

Neural tube defects (NTDs), such as exencephaly and spina bifida, occur when the neural tube fails to close properly during embryonic development. Folic acid supplementation has been shown to effectively reduce the occurrence of NTDs and low folate is a known risk factor for human NTDs. However despite extensive research, the mechanism explaining how the folate status affects the incidence of N...

background ziziphora tenuior l. known as kakuti in persian, is used in traditional medicine for fever, dysentery, uterus infection and as an analgesic. it is used also in the treatment of gastrointestinal disorders as carminative, or remedy of diarrhea or nausea. major components of plant essential oil including pulegone, isomenthone, thymol, menthone, and piperitone are suggested to be respons...

Oleanolic acid is a poorly water-soluble drug with low oral bioavailability. A self-microemulsifying drug delivery system (SMEDDS) has been developed to enhance the solubility and oral bioavailability of oleanolic acid. The formulation design was optimized by solubility assay, compatibility tests, and pseudoternary phase diagrams. The morphology, droplet size distribution, zeta potential, visco...

Nine oligosaccharides have been isolated from urine collected from an O(H), Le(a+ b-1, nonsecretor, woman during her pregnancy and subsequent lactation. One of them is a new hexasaccharide denoted lacto-N-neo-difucohexaose II: P-D-Gal-(1~4)-[ru-L-Fuc-(1~3)1-P-D-GlcNAc-(1~3)-P-DGal-(1~4)-[a-L-Fuc-(1~3)1-D-Glc. Seven of the remainder were identified as the milk oligosaccharides lacto-N-difucohexa...

BACKGROUND/AIM Diazepam is a benzodiazepine anxyolitic. Metabolism of diazepam takes place in liver which generates pharmacologically active metabolites N-desmethyldiazepam, temazepam and oxazepam. The aim of this study was to develop and validate the method of liquid chromatographymass spectrometry (LC-MS) for separation and determination of diazepam and its active metabolites in the serum of ...

This thesis consists of five parts. In the first part, an automated method for quantitative analysis of phospholipid compositions of cells and tissues by liquid chromatographymass spectrometry was developed. In the second part, this method was applied to investigate brain lipid compositions of patients with progressive epilepsy with mental retardation (EPMR), caused by mutations in the CLN8 gen...

background : rhoptries are unique secretory/excretory organelles that are found exclusively in the apicomplexa, and their contents are discharged at the time of invasion and are critical in the establishment of productive infection. several rhoptry proteins have been identified in toxoplasma gondii , plasmodium falciparum and neospora caninum and have been linked not only with the parasites’ ad...

This study evaluated the in vitro and vivo free radical scavenging potentials of methanol extract Ficus thonningii leaf its liquid chromatography-mass spectrometer (LCMS) profiling. The qualitative phytochemical screening was carried out results show presence tannins, flavonoids, saponins glycoside triterpenes. Antioxidant activities were reducing power shows a value 0.53 ± 0.007 with significa...

The aim of this work was to study the biodiesel production from cotton seed oil by lipase produced by Pichia guilliermondii lipase, which was immobilized onto hydrophobic magnetic particles (HMPs). The optimum reaction conditions were determined for lipase dosage, methanol-to-oil molar ratio, temperature and water content. Using response surface methodology, a quadratic polynomial equation was ...