Nitro-blue tetrazolium polyvinyl butyral film dosimeters (NBT-PVB) were prepared and investigated based on radiation-induced reduction of NBT. NBT-PVB film dosimeters containing different concentrations of NBT dye from 1 to 5 mM were prepared in a solution of ethanol. The dosimeters were irradiated with g-ray from Co source at doses from 5 up to 55 kGy. UV/vis spectrophotometry was used to inve...

The appropriate evaluation of measured doses in mixed fi elds requires the calibration of dosimeters in relation to different types of radiation and exposure conditions in order to split the signal into individual components corresponding to the specifi c radiation and exposure conditions of the entire period and evaluate the critical level, lower limit of detection and corresponding uncertaint...

This work investigated the suitability of passive dosimeters for reference dosimetry in small fields with acceptable accuracy. Absorbed dose to water rate was determined in nine small radiation fields with diameters between 4 and 35 mm in a Leksell Gamma Knife (LGK) and a modified linear accelerator (linac) for stereotactic radiosurgery treatments. Measurements were made using Gafchromic film (...

Changes in the linear attenuation coefficient of polymer gel dosimeters post-irradiation enable the imaging of dose distributions by x-ray computed tomography (CT). Various compositions of polymer gel dosimeters manufactured from acrylamide (AA), and N,N'-methylene-bis-acrylamide (BIS) comonomers and gelatin or agarose gelling agents were investigated. This work shows that increasing the comono...

Active and passive dosimetry instrumentation to measure absorbed dose, charged particle spectra, and linear energy transfer spectra inside the command module and orbital workshop on the NASA Skylab Program in 1972 have been developed and tested. The active doslmetry system consists of one integral unit employing both a tissue equivalent ionization chamber and silicon solld state detectors. The ...

The purpose of this study was to evaluate dependence of MAGICA polymer gel dosimeter 1/T2 on different electron energies as well as on different mean dose rates for a standard clinically used Linear accelerator. A calibration curve (in the linear region) based on 12 dosimeters (11 irradiated and one background) was obtained for 6MeV electron beam. Dose rate of dependence was studied in 10MeV el...

Chemical characterization studies for medical devices rely on extract preparation techniques such as liquid–liquid extraction to render the more amenable instrumental analysis. Considering these are generally non-targeted, effect of full range potential analytes must be considered. However, there is currently no workflow evaluating impact non-targeted extractables. Herein, we present a framewor...

Dosimetry of proton beams using 3D imaging of chemical dosimeters is complicated by a variation with proton linear energy transfer (LET) of the dose-response (the so-called 'quenching effect'). Simple theoretical arguments lead to the conclusion that the total absorbed dose from multiple irradiations with different LETs cannot be uniquely determined from post-irradiation imaging measurements on...