A brief summary of the revised NCEP guidelines for the detection, evaluation, and treatment of high blood cholesterol levels in adults is presented. The major changes in the current guidelines are the inclusion of three categories of CHD risk, one for secondary prevention and two for primary prevention based upon a combination of LDL-c levels and the number of other risk factors. Age and gender...

Thyroid hormone plays an important role in the regulation of lipid metabolism. It acts predominantly through its nuclear receptors (thyroid hormone receptor α and β) to regulate the gene expression related to lipid metabolism. Both overt hypothyroidism and hyperthyroidism result in abnormalities of lipid profile. However, changes in serum lipid profiles in patients with subclinical hypothyroidi...

Lipid disorders are a common clinical challenge in the western countries. In patients with dyslipemia (total cholesterol > 200 mg/dl, HDL cholesterol < 35 mg/dl, LDL cholesterol > 130 mg/dl and triglycerides > 150 mg/dl) it is mandatory to normalize blood pressure (<130/80 mmHg) as well to reduce LDL-C values to normal levels by using drugs to inhibit of endogenous and exogenous cholesterol, to...

Diabetes mellitus (DM) is a major risk factor for cardiovascular disease (CVD) in men and women. Type 2 is the most prevalent form of DM and is associated with a two to threefold increased risk of CVD morbidity and mortality. Insulin resistance, the fundamental defect of type 2 DM, is associated with a cluster of cardiovascular risk factors, one of which is dyslipidemia. This article discusses ...

I N 1954 SAWITSKY, HYMAN AND HYMAN reported an unidentified lipid storage disorder in two young adults characterized by the presence in the bone marrow smear of large histiocytes with numerous blue staining cytoplasmic granules.’ By 1966 only six such cases had been reported in the literature.25 A summary of clinical and laboratory findings of these cases were compiled and discussed by Thompson...

Lipid homeostasis is maintained through the coordination of lipid metabolism in various tissues, including adipose tissue and the liver. The disruption of lipid homeostasis often results in the development of metabolic disorders such as obesity, diabetes mellitus, liver steatosis, and cardiovascular diseases. Cell death-inducing DNA fragmentation factor 45-like effector family proteins, includi...

Most mechanisms involved in neuronal maintenance and function are activated at the membrane. Membrane-related molecular agents, which interact protein/lipid clusters to begin processing signal transduction, required for these functions. Furthermore, many neuropathological disorders originate this structure and/or result of membrane malfunction. Although precise maintaining "membrane health" unk...

BACKGROUND Danqi Pill (DQP), which contains Chinese herbs Salvia miltiorrhiza Bunge and Panax notoginseng, is widely used in the treatment of myocardial ischemia (MI) in China. Its regulatory effects on MI-associated lipid metabolism disorders haven't been comprehensively studied so far. We aimed to systematically investigate the regulatory mechanism of DQP on myocardial ischemia-induced lipid ...