Budesonide is a potent non-halogenated corticosteroid with high anti-inflammatory effects. The lungs are an attractive route for non-invasive drug delivery with advantages for both systemic and local applications. The aim of the present study was to develop, characterize and optimize a solid lipid nanoparticle system to deliver budesonide to the lungs. Budesonide-loaded solid lipid nanoparticle...

This paper presents a new finite element (FE) formulation for liquid shells that is based on an explicit, 3D surface discretization using C1-continuous finite elements constructed from NURBS interpolation. Both displacement-based and mixed FE formulations are proposed. The latter is needed for area-incompressible material behavior, where penalty-type regularizations can lead to misleading resul...

Objective: To prepare and evaluate lipid based drug delivery systems of Tacrolimus. Methods: Lipid based solid dispersion (SD) and self microemulsifying drug delivery systems (SMEDDS) of Tacrolimus are prepared and evaluated. Firstly, solid dispersions, liquid and solid self microemulsifying drug delivery systems of Tacrolimus were prepared. Prepared formulations were evaluated by dissolution t...

In this work rhamnolipids were evaluated as surfactants for the production of nanostructured lipid carriers (NLCs). NLCs produced by melt-emulsification using ultra-homogenisation followed ultrasonication and different ratios medium-chain-triglycerides glycerol monostearate (lipid phase) tested. presented sizes polydispersity index values ranged between 97 120 nm 0.20–0.26, respectively. Transm...

Poorly water-soluble drugs demonstrate significant challenge in pharmaceutical development, which is linked to their limited oral bioavailability and therapeutic efficacy. To overcome these limitations, lipid-based formulations have emerged as a promising approach enhance the delivery of such drugs. Moreover, encapsulation within capsules provide convenient dosage form for administration. The t...