Polyunsaturated fatty acids (PUFAs) have anti-inflammatory effects at low concentrations; however increased dietary consumption may conversely increase susceptibility to oxidation by free radicals. The objective of this study was to determine the effects of PUFAs on selective oxidative injury and inflammatory biomarkers in canine urine and serum. Dogs (n = 54) consumed a diet supplemented with ...

The objective of this study was to compare the effects of linoleic acid (cis,cis-C18:2(n-6)) and its hydrogenation products elaidic (trans-C18:1(n-9)) and stearic acid (C18:0) on serum lipoprotein levels in humans. Twenty-six men and 30 women, all normolipemic and apparently healthy, completed the trial. Three experimental diets were supplied to every subject for 3 weeks each, in random order (...

Previous studies have shown that the quantity of oxidized lipids in the diet directly correlates with the level of oxidized chylomicrons in mesenteric lymph and the level of oxidized lipids in endogenous lipoproteins such as very low density lipoprotein (VLDL) and low density lipoprotein (LDL). The aim of the present study was to determine whether oxidized fatty acids in the diet are delivered ...

AIMS To investigate how linoleic acid affects conidial production and sclerotial development in a strictly mitotic Aspergillus parasiticus field isolate as related to improving biocompetitivity of atoxigenic Aspergillus species. METHODS AND RESULTS We disrupted A. parasiticusDelta12-oleic acid desaturase gene (odeA) responsible for the conversion of oleic acid to linoleic acid. We examined co...

Background: Feeding unsaturated fatty acids sources in dairy cows is considered as a strategy to improve animal health during postpartum period and milk fatty acid profile. OBJECTIVES: This study aimed to investigate the effects of conjugated linoleic acid supplement and combination of sesame meal and oil on performance and milk fatty acid composition of dairy cows during transition period. MET...

The linoleic acid content of serum lipids was measured in 47 patients with multiple sclerosis, 29 patients with other neurological diseases, 35 patients with acute non-neurological illnesses, and 49 healthy control subjects. Reduced linoleic acid content of serum lipids was not specific to multiple sclerosis and occurred in all ill patients with acute non-neurological illness. The fatty-acid pa...

di-cis-decadienyl structure are apparently required for maintenance of normal growth and reproduction (16). The commonly occurring fatty acids exhibiting this structural moiety are linoleic (18 :2w6)', linolenic (1 8:3w3), and arachidonic acids (20:4co6). Since they are not synthesized de novo, they have been termed the â€oeEFA's.†• 2 A dietary requirement for these fatty acids has been shown...

The aim was to determine the conjugated linoleic acids in beef with GC-FID. Perfect separation of all of the isomers cannot be achieved, though conjugated linoleic acid isomers proved to be separable from the other fatty acids that are present in beef in a significant amount related to conjugated linoleic acids. Lipid-extraction was carried out with n-hexane/i-propanol, giving 6.8 percent highe...

Kidney prostaglandlns appear to bare powerful Influences on Nad-Induced hypertension. In quick-frozen kidneys, the concentration of prosUglandin E, (PGE,) in the renal papilla is 60% lower in Dahl S rats than in Dahl R rats (17 ng/100 mg TS 42 ng/100 mg,p < 0.01) when both S and R rats are fed a 0.3% low NaCI diet. When S and R rats eat a 4% high NaCl diet for 4 weeks or 11 weeks, the PGE, conc...