This study examines whether both the trend and the increase in variance of the Northern Hemisphere winter annular mode during the past 30 years arise from atmospheric internal variability. To address this question, a synthetic time series is generated that has the same intraseasonal stochastic properties as the annular mode. By generating a distribution of linear trend values for the synthetic ...

BACKGROUND Granuloma annulare is a granulomatous disease of unknown etiology. Various therapies have been tried in disseminated granuloma annulare (DGA), including corticosteroids, several variants of psoralen plus ultraviolet-A radiation, ultraviolet- A1 radiation, systemic retinoids, and dapsone, with variable success. We report a patient with recalcitrant DGA who was treated with fumaric aci...

Granuloma annulare (GA) is a benign and typically selflimiting granulomatous disease of unknown etiology; it tends to resolve spontaneously over a period of months or years. It usually presents with annular lesions on the hands, upper limbs, trunk, or lower limbs; facial involvement is rare. It is associated with diabetes mellitus, paraneoplastic disorders, thyroid disturbances, and some drugs....

Granuloma annulare (GA) is a benign and typically selflimiting granulomatous disease of unknown etiology; it tends to resolve spontaneously over a period of months or years. It usually presents with annular lesions on the hands, upper limbs, trunk, or lower limbs; facial involvement is rare. It is associated with diabetes mellitus, paraneoplastic disorders, thyroid disturbances, and some drugs....

BACKGROUND Defects in protein folding may lead to severe degenerative diseases characterized by the appearance of amyloid fibril deposits. Cytotoxicity in amyloidoses has been linked to poration of the cell membrane that may involve interactions with amyloid intermediates of annular shape. Although annular oligomers have been detected in many amyloidogenic systems, their universality, function ...

In this work, the optimization for a radiative-convective annular fin of arbitrary profile with base wall thermal resistances is considered. A fourth order Runge-Kutta method is used to solve the associated non-linear governing equations. Further differentiations yield the optimum heat transfer and the optimum fin dimensions. To facilitate the thermal design, design charts for optimum dimension...

A middle-aged man with no symptom or history visited our hospital due to duodenal abnormality and fecal occult blood detected by health screening. Upper gastrointestinal endoscopy showed marked enlargement of the papilla of Vater surrounded by nodules, and biopsy disclosed non-caseating granuloma. Colonoscopy yielded findings suggestive of intestinal tuberculosis such as annular ulcers. Examina...