BACKGROUND Within mixtures, interactions between different xenobiotics may occur to give rise to additive, synergistic, inhibitory and/or stimulatory effects in target cells. The role that xenobiotics individually or in mixtures, and at environmental concentrations, play in the etiology of common human diseases often remains obscure. METHODS In the presence or absence of lindane, chromosomal ...

A bioassay for possible carcinogenicity of lindane was conducted by administering the test chemical in the diet to Osborne-Mendel rats and B6C3F1 mice. Groups of 50 rats of each sex were administered lindane at one of two doses for 80 weeks, then observed for 29-30 weeks. Time-weighted average doses for males were 236 or 472 ppm; those for females were 135 or 270 ppm. Matched controls consisted...

Abstract The potential for the photocatalytic degradation of lindane, used as agricultural insecticide and pharmaceutical product, is investigated. Two types photocatalysts, immobilized on 5 mm sodalime beads are synthesised using an easy economical process: (1) Zinc Oxide (ZnO) nanoparticles (2) Iron oxide-doped (Fe-ZnO). Tests lindane under continuous flow conditions conducted a stainless ste...

Treatment of WB-F344 rat liver epithelial cells with DDT (1,1-bis(p-chlorophenyl)-2,2,2-trichloroethane) or lindane induces a loss of gap junction plaques and a decrease in the phosphorylated gap junction protein connexin43-P2 (Cx43-P2), which is associated with the plaques. In this study we have considered several mechanisms. The loss of junctional plaques could be due to disaggregation of jun...

A new approach for the removal of the pesticide lindane (gamma-hexachlorocyclohexane or gamma-HCH) makes use of catalytic reduction of HCH to benzene over a metal catalyst, namely Pd(0). Since specific surface area plays an important role in reactivity of catalysts, this study investigated the use of bioPd(0), i.e. nano-scale Pd(0) particles precipitated on the biomass of Shewanella oneidensis,...

The organochlorine chemicals endosulfan, dieldrin, and γ-hexachlorocyclohexane (lindane) are persistent pesticides to which people are exposed mainly via diet. Their antagonism of the γ-aminobutyric acid-A (GABA(A)) receptor makes them convulsants. They are also endocrine disruptors because of their interaction with the estrogen receptor (ER). Here, we study the effects of dieldrin, endosulfan,...