this study presents the influence of hydroxypropyl-β-cyclodextrin (hpbcd) on the aqueous solubility of acyl esters of cyproterone. first, a number of esters of cyproterone were synthesized. then the phase solubility analysis of the compounds in the presence of hpbcd was investigated in phosphate buffer solution at a ph of 7.4. to gain a better understanding of the complexation mechanism, the sy...

diosmin, a vascular-protecting agent, is practically insoluble in water, and its oral absorption is limited by its extremely low dissolution rate. in this study, β-cyclodextrin (βcd) and 2-hydroxypropyl-β-cyclodextrin (hpβcd) were obtained to improve the solubility and dissolution rate of diosmin. phase solubility studies of diosmin with βcd and hpβcd in distilled water were conducted to charac...

it is well known that a microperiodic function mapping a topological group into reals, which is continuous at some point is constant. we introduce the notion of a microperiodic multifunction, defined on a topological group with values in a metric space, and study regularity conditions implying an analogous result. we deal with vietoris and hausdorff continuity concepts.stability of microperiodi...

The inclusion of pharmacists in the healthcare system of a developing country like Pakistan has always been a subject of debate among the healthcare professionals (HCPs), especially physicians, who have long ruled the healthcare system alone and who have had a long-held position of supremacy. The common argument against the inclusion of pharmacists is the dynamics of the healthcare system, and ...

Inclusion bodies are nuclear or cytoplasmic aggregates of proteins that may be formed due to infections or genetic disorders. Asteroid body is one such inclusion that is eosinophilic and spider like that are usually found in infections like sarcoidosis and sporotrichosis. Inclusions are usually pathognomonic of certain diseases and conditions, navigating the pathologist to arrive at a diagnosis...

In this paper, a new class of (h, η)-proximal mappings for proper functionals in Hilbert spaces is introduced. The existence and Lipschitz continuity of the (h, η)-proximal mappings for proper functionals are proved. A class of generalized nonlinear quasi-variational-like inclusions in Hilbert spaces is introduced. A perturbed three-step iterative algorithm with errors for the generalized nonli...

domperidone is a widely used antiemetic, poorly water soluble drug, erratically absorbed in stomach and possess several dissolution-related problems thus it has poor bioavailability. solubility of a drug plays a very important role in dissolution and hence absorption of drug which ultimately affects its bioavailability. hence, by considering the facts related to drug, attempts have been made to...

BACKGROUND Formation of inclusion bodies poses a major hurdle in recovery of bioactive recombinant protein from Escherichia coli. Urea and guanidine hydrochloride have routinely been used to solubilize inclusion body proteins, but many times result in poor recovery of bioactive protein. High pH buffers, detergents and organic solvents like n-propanol have been successfully used as mild solubili...

the komshecheh barite-fluorite deposit is the product of epigenetic hydrothermal mineralizationin dolomitized limestone of middle triassic age. the deposit is structurally and lithologically controlled andoccurs predominantly as bedded stratabound replacement sheets, although the veins and solution-collapsebreccias constitute important modes of occurrence. brecciation, dolomitization, silicific...

abstractepidermal inclusion cysts are uncommon in the breast, but the consequences can besevere when these cysts occur in the breast parenchyma. here, we report two suchcases. the patient in case 1 was an 37-year-old woman with a 3-cm palpable mass inthe right breast. mammography revealed a round and smoothly outlined mass, whichindicated a benign tumor, and sonography showed an irregularly sha...