INTERNATIONAL LICENSING AND THE STRENGTHENING OF INTELLECTUAL PROPERTY RIGHTS IN DEVELOPING COUNTRIES DURING THE 1990S ........................ 7 Walter G. Park and Douglas Lippoldt This paper assesses the effect of strengthened intellectual property rights in developing countries on international licensing activity. The analysis draws on indicators for four dimensions of intellectual property ...

To evaluate the usefulness of computerized adaptive testing (CAT) in medical school, the General Examination for senior medical students was administered as a paper and pencil test (P&P) and using CAT. The General Examination is a graduate examination, which is also a preliminary examination for the Korean Medical Licensing Examination (KMLE). The correlations between the results of the CAT and...

This paper investigates in an exploratory manner the licensing strategies pursued by firms whose business model is based on developing and licensing out their intellectual property rights (IPRs). These are not traditional suppliers, since they do not engage in production or commercialization, but focus solely on invention. While considerable anecdotal evidence exists about these IP vendors, the...

HBO1, an H4-specific histone acetylase, is a coactivator of the DNA replication licensing factor Cdt1. HBO1 acetylase activity is required for licensing, because a histone acetylase (HAT)-defective mutant of HBO1 bound at origins is unable to load the MCM complex. H4 acetylation at origins is cell-cycle regulated, with maximal activity at the G1/S transition, and coexpression of HBO1 and Jade-1...

Eukaryotic replication origin licensing, activation and timing are influenced by chromatin but a mechanistic understanding is lacking. Using reconstituted nucleosomal DNA replication assays, we assessed the impact of nucleosomes on replication initiation. To generate distinct nucleosomal landscapes, different chromatin-remodeling enzymes (CREs) were used to remodel nucleosomes on origin-DNA tem...

Regulatory inactivation of DnaA (RIDA) is one of the major regulatory mechanisms of prokaryotic replication licensing. In RIDA, the Hda-sliding clamp complex loaded onto DNA directly interacts with adenosine triphosphate (ATP)-bound DnaA and stimulates the hydrolysis of ATP to inactivate DnaA. A prediction is that the activity of Hda is tightly controlled to ensure that replication initiation o...