Short title: Zika protease pocket susceptible to allosteric inhibition The authors have declared that no competing interests exist. ABSTRACT It has been recently estimated that one-third of the world population will be infected by Zika virus, but unfortunately so far there is no vaccine or medicine available. In particular, the special concern on the vaccine treatment to Zika and Dengue arising...

BACKGROUND Burn is the most devastating condition in emergency medicine leading to chronic disabilities. This study aimed to compare the effect of Lithospermum officinale, silver sulfadiazine and alpha ointments on healing of burn wounds in rat. METHODS Ninety-five rats were divided into 5 groups. Group 1 just underwent burn injury, and groups 2-5 received alpha ointment, silver sulfadiazine ...

Orchidaceae is the second largest family of flowering plants, which is highly valued for its ornamental purposes and medicinal uses. Dendrobium officinale is a special orchid species that can grow without seed vernalization. Because the whole-genome sequence of D. officinale is publicly available, this species is poised to become a convenient research model for the evolutionary, developmental, ...

Obesity has become a worldwide health problem. Orlistat, an inhibitor of pancreatic lipase, is currently approved as an anti-obesity drug. However, gastrointestinal side effects caused by Orlistat may limit its use. In this study the inhibitory activities of dandelion (Taraxacum officinale) against pancreatic lipase in vitro and in vivo were measured to determine its possible use as a natural a...

An investigation was carried out to evaluate the insecticidal activity of Allium sativum, Zingiber officinale and Nigella sativa extracts against the larvae of T. granarium under laboratory conditions in the University of Agriculture, Faisalabad, Pakistan during 2009-10. The highest concentration of (6 %) Z. officinale was found to be comparatively more toxic (16.70 %) than those of A. sativum ...

objective diabetes mellitus is manifested by hyperglycaemia. different treatments such as diets and drugs are recommended for diabetes control. for various reasons in recent years traditional plant (herbal) therapies as prescribed by indigenous systems of medicine with different mechanisms have commonly been used. the digestive enzymes such as alpha glucosidase are among these herbal remedies. ...

Koch curve is known as a typical self-similar set on Euclidean plane. Koch island is a closed set surrounded by three copies of Koch curve. We investigate them from the viewpoint of computability. In this paper, we define computability of a curve and that of a closed set as an application of classical computable analisys to Euclidean spaces and show that Koch curve is a computable curve and bot...

Abstr Zingiber officinale and Alpinia allughas are used in Chinese, Ayurvedic and Tibb-Unani herbal medicines all over the world for a wide array of ailments. Presenet study was carried out to determine chemical composition and minerals contents of Zingiber officinale and Alpinia allughas rhizomes. Samples were collected from local retail market of Faisalabad, Pakistan. Moisture, ash, crude fib...

abstract background: using non-pharmacological pain relief methods for reducing labor pain has always been one of the major concerns in obstetrics and gynecology. objective: comparing the effects of aromatherapy with jasmine and salvia on pain severity and labor outcome in nulliparous women. materials and methods: in this randomized clinical trial, 156 nulliparous women in labor were randomly s...

The regularities of natural (K-40, Th-232, Ra-226) and artificial (Sr-90 and Cs-137) radionuclides accumulation by embryonic soils and various organs of Taraxacum officinale Web. in rock waste disposal areas of the Kedrovsky coal pit in the Kuznetsk Basin were studied. The K-40 natural radionuclide causes major radioactivity of embryonic soils at rock waste disposal areas – its share in the tot...