Abstract Siglec-15 (Sig15) has been implicated as an immune checkpoint expressed in solid tumor-infiltrating macrophages and is being targeted clinical trials with monoclonal antibodies to normalize the tumor microenvironment stimulate anti-tumor immunity. However, role of Sig15 hematological malignancies remains undefined. mRNA protein expression levels were determined from publicly available ...

purpose: to report a case of acute myelogenous leukemia (aml) presenting with periorbital cellulitis and progressing to facial and neck cellulitis. case report: a 17 year old male patient presented with periorbital cellulitis which progressed to the right hemifacial and neck area. he did not respond to regular antibiotic therapy. peripheral blood smear showed leukocytosis with predominance of i...

histone deacetylases (hdacs) are the enzymes causing deacetylation of histone and non-histone substrates. histone deacetylase inhibitors (hdis) are a family of drugs eliminating the effect of hdacs in malignant cells via inhibition of hdacs. due to extensive effects upon gene expression through interference with fusion genes and transcription factors, hdacs cause proliferation and migration of ...

FMS-like tyrosine kinase-3 is a receptor tyrosine kinase expressed by immature hematopoietic cells and is important for the normal development of stem cells and the immune system. Mutations of FMS-like tyrosine kinase-3 have been detected in about 30% of patients with acute myelogenous leukemia and a small number of patients with acute lymphoblastic leukemia. The FMS-like tyrosine kinase-3 muta...

background and objective: vascular endothelial growth factor (vegf) is a cytokine which is overexpressed in many malignant cancers including leukemia. vegf plays an important role in tumor invasion and metastasis. determination of the pattern of vegf expression in human leukemic cell lines could be useful not only in screening of new antileukemic agents but also to study the mechanism of their ...

Leukemoid reaction like leukemia indicates noticeable increased count of WBCs (White Blood Cells) but the cause it is due to severe inflammation or infections in other body regions. In automatic diagnosis classifying and leukemoid reactions, ALL IDB2 (Acute Lymphoblastic Leukemia-Image Data Base) dataset has been used which comprises 110 training images blast cells healthy cells. This paper aim...

Objective: This study evaluated the antiproliferative and pro-apoptotic effects of coenzyme Q0 (CoQ0) in human chronic myeloid leukemia K562 cell line. Material Method: The cytotoxic effect CoQ0 on line, was determined by MTT test. activity caspase-3, expression proteins involved apoptosis, MAPK AKT signaling pathways were with enzymatic assay western blot analysis, respectively. Result Discuss...

Recently wild-type p53-induced phosphatase was implicated in the pathogenesis of acute myeloid leukemia (AML) and “pre-leukemia” myeloproliferative conditions. Here we decided to check how strategy directed inhibition affected sensitivity conventional chemotherapy. All experiments were conducted on AML cell lines cultivated vitro. The levels vary different lines. chemical compound GSK2830371 re...