Self-destructive behavior in the adolescent is a continuum that ranges from drug intoxications to gestures of low lethality to suicide attempts with high lethality of intent. Such behavior should be treated as a signal of long-term stress and strife. A "Psychological biopsy" is outlined for evaluation of the severity and type of perturbation. This focuses on 9 areas of inquiry: the circumstanti...

Abstract Excess platelet activation by extracellular vesicles (EVs) results in trophoblast inflammasome activation, interleukin 1? (IL-1?) preeclampsia (PE), and partial embryonic lethality. Embryonic thrombomodulin (TM) deficiency, which causes lethality hallmarked impaired proliferation, has been linked with maternal activation. We hypothesized that placental TM loss, are mechanistically to H...

The immunomodulatory activity of Cod liver oil (CLO) was evaluated by mice lethality test, carbon clearance assay, neutrophil adhesion test, cyclophosphamide-induced neutropenia, indirect haemagglutination test and effect on serum immunoglobulin levels. CLO was administered orally at a dose of 0.5 g/kg or 1 g/kg body weight. In mice lethality test, low dose of CLO (0.5 g/kg, po) produced 40% de...

Intrinsic postzygotic reproductive isolation is thought to result from the substitution of multiple harmless or beneficial genetic differences between species that are incidentally deleterious when combined in species hybrids, causing hybrid sterility or inviability. Genetic variability for hybrid sterility or inviability phenotypes is, however, rarely assessed in natural populations. Here, we ...

An unexpected high level of acute lethality has been documented following Photofrin II-mediated photodynamic therapy (PDT) treatments which were localized to the hind leg of normal and tumor-bearing mice. Doses of PDT which induced lethality (10 mg/kg Photofrin II, 200-500 J/cm2) were in the range of doses required to obtain murine tumor cures. The percentage of lethality was proportional to th...

Traditionally, human cadavers and porcine tissue have been used as means to replicate elements of the body; however, because differences in biomechanical properties from limbs/organs potential for degradation mechanical caused by ageing, they do not provide accurate material either lethality or survivability assessment. In 21st century with more ethical ways working being employed, use soft ana...

Intracranial pressure (ICP) belongs among relevant physiological parameters that are advised to be monitored at emergency units with patients after severe traumatic brain injury. However no advanced tools in a form of alarm based on ICP time series were developed. Procedure for assessment regarding actual degree of lethality is presented. ICP time segments and its derived features are applied i...

Vitamin A and its derivatives have recently reported to be implicated in synaptic plasticity. The possible effect of vitamin A and its precursor, ?-carotene, on seizure acquisition was tested in PTZ kindling model of epilepsy. Vitamin A and ?-carotene were tested for their ability to 1) suppress seizures (clonic and tonic) and lethality induced by PTZ in PTZ-kindled mice (anticonvulsant effect)...

the immunomodulatory activity of cod liver oil (clo) was evaluated by mice lethality test, carbon clearance assay, neutrophil adhesion test, cyclophosphamide-induced neutropenia, indirect haemagglutination test and effect on serum immunoglobulin levels. clo was administered orally at a dose of 0.5 g/kg or 1 g/kg body weight. in mice lethality test, low dose of clo (0.5 g/kg, po) produced 40% de...