Mycoplasma arthritidis induces an acute to chronic arthritis in rodents. Arthritis induced in mice histologically resembles human rheumatoid arthritis and can be associated with lethal toxicity following systemic injection. The M. arthritidis mitogen (MAM) superantigen has long been implicated as having a role in pathogenesis, but its significance with respect to toxicity and arthritogenicity i...

The influence of water chemistry on characterised polyvinyl pyrrolidone- (PVP-) coated silver nanoparticles (81 nm) was investigated. NaCl solution series of 100-800 mg L(-1) lead to initial and temporal increase in nanoparticles size, but agglomeration was limited. pH variation (5-8) had only minor influence on the hydrodynamic particle size. Acute toxicity of nanosivler to zebrafish (Danio re...

I performed laboratory bioassays to characterize the acute contact toxicity of oxalic acid (OA) to Varroa destructor (Anderson & Trueman) and their honey bee hosts (Apis mellifera). Specifically, I conducted glass-vial residual bioassays to determine the lethal concentration of OA for Varroa, and I conducted topical applications of OA in acetone to determine the lethal dose for honey bees. The ...

Despite the risk of cyanide toxicity and lack of efficacy, amygdalin is still used as alternative cancer treatment. Due to the highly lethal nature of cyanide toxicity, many patients die before getting medical care. Herein, we describe the case of a 73-year-old female with metastatic pancreatic cancer who developed cyanide toxicity from taking amygdalin. Detailed history and physical examinatio...

OBJECTIVE Chlorpyrifos (CPF) is a neurotoxic organophosphorus (OP) insecticide. Its mechanism of action includes oxidative stress, excitotoxicity, and inhibition of the acetylcholinesterase enzyme (AChE). The aim of the present study is to investigate CPF toxicity in mature and immature cerebellar granule neurons (CGNs), as well as its effect on glutamate induced excitotoxicity. MATERIALS AND...