tuberculosis is one of the most common infectious diseases in the world. in recent years, genetically approach has been developed. one of the interesting gene for investigator is ifn-γr1. in this study we determind susceptibility to tuberculosis with polymorphism of ifn-γr1 gene. fifthly patients with smear positive tuberculosis have been chosen randomly. they were matched with 54 healthy contr...

background: potential association of leptin (lep) gene polymorphisms has been suggested in the processes leading to breast cancer initiation and progression. we investigated whether genetic variations in the lep -2548g/a gene are associated with risk of breast cancer. methods: this case-control study consisted of 100 breast cancer cases and 100 control subjects without breast cancer that matche...

Introduction:Obesity is one of the most serious challenges of our era, with significant health consequences and high economic burden for health systems. Therefore, many countries have developed political agendas to cope with this ever-rising challenge. Along with chemical medications that are developed to manage obesity, researchers have focused on some natural ingredients and herbal extracts w...

background: progesterone has been suggested to contribute to the regulation of spermatogenesis and to facilitate the production of viable sperm. investigations have showed that polymorphism of progesterone receptor (pgr) is associated with some diseases. objective: to analyze the potential relationship between male infertility and the +331g/a and progins polymorphisms of pgr gene. materials and...

OBJECTIVE Investigate the association between polymorphisms in the leptin receptor gene associated with obesity and gallstone disease. DESIGN We conducted a cross-sectional study, carried out at a tertiary setting. SUBJECTS We enrolled 97 subjects, comprising 54 subjects with gallstones (cases) and 43 controls (without gallstones). MEASUREMENTS Diet was assessed using a validated question...

Osteoporosis is a systemic skeletal disease and there is a close relationship between the sympathetic nervous system (SNS) and bone metabolism. Leptin has been shown to regulate bone formation and bone resorption via the SNS. However, the effect of SNS on leptin signaling has not been clearly understood. In the present study, we studied the effect of propranolol on ovariectomy-induced osteoporo...

A total of 181 Jersey cows were used to investigate how leptin gene polymorphisms affect somatic cell count (SCC) in milk. Three single nucleotide polymorphisms were genotyped, namely the R4C polymorphism in exon 2, the Sau3AI polymorphism in intron 2 and the A59V polymorphism in exon 3. The genotype and allele frequencies for each polymorphism and the haplotype frequencies for all polymorphism...

BACKGROUND Obesity has been associated with leptin resistance and this might be caused by genetic factors. The aim of this study was to investigate the gene-lifestyle interaction between -866G/A UCP2 (uncoupling protein 2) gene polymorphism, dietary intake and leptin in a population based study. METHODS This is a cross sectional study conducted in adults living at urban area of Yogyakarta, In...

This article shows the results of studies in course which a comparative aspect LEP polymorphism was studied subpopulations Holstein dairy cattle cows with fatty hepatosis and healthy animals. is first time such are being conducted. In this case, hepothesis about relationship genetic markers, particular leptin gene, risk developing progression liver disease model when determining frequency occur...