KEY POINTS Ca leak from the sarcoplasmic reticulum through the ryanodine receptor (RyR) reduces the amplitude of the Ca transient and slows its rate of decay. In the presence of β-adrenergic stimulation, RyR-mediated Ca leak produces a biphasic decay of the Ca transient with a fast early phase and a slow late phase. Two forms of Ca leak have been studied, Ca-sensitising (induced by caffeine) an...

Background: Bile duct leak is an infrequent but serious disorder. The great majority occurs after hepatobiliary surgery. Early recognition and adequate multidisciplinary approach is the cornerstone for the optimal final outcomes. Traditionally, surgery has been the gold standard for the management of bile leak, but it is associated with significant morbidity and mortality. Biliary endoscopic pr...

results the mean age was 45.6 ± 13.1 (24 to 74 ) years. twenty-two were normal responders [considered as non-organic causes (37.3% of all patients)], 27 were classified as venous leakage, eight had arterial insufficiency and two were mixed type. maximum psv occurred before the fifth minute in 47 patients (92.2%). eight patients completed all phases of erection in the first 5 minutes. we defined...

PURPOSE To assess whether the presence and duration of air leaks after lobectomy are associated with an increased incidence of cardiopulmonary complications. METHODS Propensity score analysis was used on 726 patients undergoing pulmonary lobectomy from 1995 through 2004 to form three well-matched pairs of patients: patients with prolonged air leak (PAL) [> 7 days] and without air leak; patien...

INTRODUCTION The cuff-leak test has been proposed as a simple method to predict the occurrence of post-extubation stridor. The test is performed by cuff deflation and measuring the expired tidal volume a few breaths later (VT). The leak is calculated as the difference between VT with and without a deflated cuff. However, because the cuff remains deflated throughout the respiratory cycle a volum...

Refrigeration service personnel have used leak detection equipment for years when servicing refrigeration equipment. In the past, leak detection typically was only concerned with leak pinpointing, either with an ultrasonic device, soap bubbles, dyes, thermal conductivity, or other electronic devices. Today, refrigerant leak detectors exist not only for pinpointing leaks, but also for monitoring...