BACKGROUND The sodium-glucose co-transporter-2 (SGLT-2) inhibitors have been reported to increase both low-density lipoprotein (LDL) and high-density lipoprotein (HDL)-cholesterol (C). This study aimed to determine how SGLT-2 inhibitors affect LDL and HDL-C subspecies. METHODS This single center, open-label, randomized, prospective study included 80 patients with type 2 diabetes taking prescr...

BACKGROUND Low-density lipoprotein cholesterol (LDL-C) is the traditional measure of risk attributable to LDL. Non-high-density lipoprotein cholesterol (NHDL-C), apolipoprotein B (apoB), and LDL particle number (LDL-P) are alternative measures of LDL-related risk. However, the clinical utility of these measures may only become apparent among individuals for whom levels are inconsistent (discord...

The purpose of this study was to evaluate the LipiDirect assay (L-LDL) against the Direct LDL immunoseparation method (D-LDL) and beta quantification (BQ-LDL) for measurement of LDL cholesterol (LDL-C) in patients with normo- and hypertriglyceridemia. Samples from 156 patients [triglyceride (Tg) range 0.61-9.95 g/L] were assayed for LDL-C concentrations with the three methods. An additional sev...

Background and aims: Mendelian randomization studies have shown that triglyceride (TG)- lowering lipoprotein lipase (LPL) alleles low-density lipoprotein-cholesterol (LDL-C)-lowering independent beneficial associations on cardiovascular disease (CVD) risk. We aimed to provide further insight into this observation by applying analyses of genetically-influenced TG LDL-C levels plasma metabolomic ...

Overweight and obesity is a major health problem in throughout the world. Hyperlipidemia are risk factor occurrence of cardiovascular disease. Exercise recommended as therapeutic lifestyle changes because it leads to variety benefits. Fun Aerobic gymnastics aerobics one which quite popular community gym. Describe fun aerobic workout's effectiveness against related prevention disease with seeing...

AIM Low-density lipoprotein cholesterol (LDL-C), the ratio of LDL-C to high-density lipoprotein cholesterol (HDL-C; LDL-C/HDL-C), and non-HDL-C were evaluated to determine their ability to predict cardiovascular disease (CVD) risk with pravastatin treatment. METHODS We conducted a large-scale randomized primary prevention trial in Japan (MEGA Study), in which we randomly allocated 7832 mild h...