A new very simple single phase ac-ac voltage regulator based on LC network is proposed here that compensates wide range supply voltage variations. This has the capability of both buck and boost the input source voltage level without any change of phase angle. The number of components used in the converter circuit is minimum and smooth output waveform can be achieved without any additional filte...

introduction: previous studies have shown that stimulation of lateral hypothalamus (lh) produces antinociception. orexin-a (oxa) receptor is strongly expressed in the nucleus locus coeruleus (lc) and orexinergic fibers densely project from lh to lc. in this study, we assessed the role of lc and its oxa receptors in antinociceptive response induced by lh chemical stimulation in the rat. methods:...

In mammals, the pontine nucleus locus ceruleus (LC) is the sole source of norepinephrine (NE) projections to the forebrain. Increasing tonic discharge of LC neurons elevates extracellular levels of NE in the cortex and thalamus. Tonic LC discharge is linked to the level of wakefulness and behavioral performance, demonstrating an optimal firing rate during sustained attention tasks. Iontophoreti...

Langerhans cells (LC) are a unique population of tissue-resident macrophages that form a network of cells across the epidermis of the skin, but which have the ability to migrate from the epidermis to draining lymph nodes (LN). Their location at the skin barrier suggests a key role as immune sentinels. However, despite decades of research, the role of LC in skin immunity is unclear; ablation of ...

In this paper, we describe an original method for determining the optimal operating point of the active part (transistor) of an LC oscillator leading to the minimum phase noise for given specifications in terms of power consumption, oscillation frequency and for given devices (i.e., transistor and resonator). The key point of the proposed method is based on the use of a proper LC oscillator arc...

Cutaneous squamous cell carcinoma (SCC) is the most prevalent invasive malignancy with metastatic potential. The epidermis is exposed to a variety of environmental DNA-damaging chemicals, principal among which are polyaromatic hydrocarbons (PAHs) ubiquitous in the environment, tobacco smoke, and broiled meats. Langerhans cells (LCs) comprise a network of dendritic cells situated adjacent to bas...

The aim of this study was to investigate the influence of long fibre concentration on loadability and pulp properties during LC refining of mechanical pulp. Long fibre concentration was adjusted to three different levels by screen fractionation of the pulp. The three pulps were refined in a single disc pilot scale LC refiner at similar process conditions. Increased long fibre concentration supp...

BACKGROUND Clinical trials of human epidermal growth factor receptor 2 (HER2)-targeted agents added to standard treatment have been efficacious for HER2-positive (HER2+) advanced breast cancer. To our knowledge, no meta-analysis has evaluated HER2-targeted therapy including trastuzumab emtansine (T-DM1) and pertuzumab for HER2-positive breast caner and ranked the targeted treatments. We perform...