Low birth weight (LBW) is associated with increased risk of the development of type 2 diabetes (T2D). The appetite-regulating hormone leptin is released from mature adipocytes, and its production may be decreased in immature preadipocytes from LBW individuals. We recruited 14 men born with LBW and 13 controls born with normal birth weight (NBW). Biopsy samples were obtained from subcutaneous ab...

Several studies have linked low birth weight (LBW) and type 2 diabetes. We investigated hepatic and peripheral insulin action including intracellular glucose metabolism in 40 19-year-old men (20 LBW, 20 matched control subjects), using the hyperinsulinemic-euglycemic clamp technique at two physiological insulin levels (10 and 40 mU/m(2) per min), indirect calorimetry, and [3-(3)H]glucose. Insul...

Individuals born with low birth weight (LBW) are at risk of developing type 2 diabetes mellitus (T2D), which may be precipitated by physical inactivity. Twenty-two LBW subjects and twenty-three controls were studied before and after bed rest by the hyperinsulinemic euglycemic clamp combined with indirect calorimetry and infusion of stable isotope tracers and preceded by an intravenous glucose t...

Objective: Thyroid disorder is a common endocrine complication in pregnant women: the association between neonatal low birth weight (LBW) and thyroid dysfunction during pregnancy has not been definitely confirmed. We conduct a systematic literature review and meta-analysis of the adverse fetal complication of LBW in maternal thyroid disease, including overt and subclinical hyperthyroidism and h...

Malaria during pregnancy can result in low birth weight (LBW), an important risk factor for infant mortality. This article reviews the pathological effects of malaria during pregnancy and the implications for the newborn's development and survival. Empirical data from throughout Africa on associations between placental malaria and birth weight outcome, birth weight outcome and infant mortality,...

BACKGROUND Low birth weight deliveries are major causes of a huge health burden on poor economies around the globe. It is even more worrisome in developing countries. MATERIALS AND METHODS The obstetric records of all low birth weight (LBW) deliveries were reviewed from 1 st June 2005 to 30 th May 2009. RESULTS The prevalence of LBW deliveries was 8.3%. Of the LBW babies, 68.4% were preterm...

OBJECTIVE To study the prevalence of low birth weight (LBW) and its association with maternal factors. DESIGN Cohort study. SETTING Urban community. SUBJECTS Cohort of 210 pregnant women. RESULTS The LBW prevalence was 30.3%. On multivariate analyses the maternal factors significantly associated with LBW were anemia (OR-4.81), low socioeconomic status (OR-3.96), short birth interval (OR...

BACKGROUND Low birth weight (LBW) remains a leading global cause of childhood morbidity and mortality. This study leverages a large national survey to determine current prevalence and socioeconomic, demographic and heath related factors associated with LBW in Bangladesh. METHODS Data from the Multiple Indicator Cluster Survey (MICS) 2012-13 of Bangladesh were analyzed. A total of 2319 women f...

CONTEXT Low birth weight (LBW) predicts later-onset hypertension and diabetes mellitus. Its role as a predictor of depression is unclear. OBJECTIVES To examine whether LBW predicts depression in male and female children and adolescents and to compare the following 2 hypotheses: Low birth weight is one among several perinatal, childhood, and adolescent risk factors for depression (biopsychosoc...

BACKGROUND Little is known about the interaction between gender and low birth weight (LBW) and lifelong social mobility as an explanation of the etiology of obesity. The aim of the present study was to evaluate total and central obesity according to gender, LBW and social mobility, within the context of the epidemiological transition in middle-income countries. We hypothesize that there are mor...