To investigate the possible role of the superoxide radical and its scavenging system in the human endometrium, the immunohistochemical distribution of superoxide dismutase (SOD), activities of SOD and lipid peroxide concentrations were studied in the human endometrium throughout the menstrual cycle and in early pregnancy. The endometrial epithelium showed a positive immunostaining for Cu, Zn-SO...

BACKGROUND Antenatal anaemia, iron deficiency and common mental disorders (CMD) are prevalent in low- and middle-income countries. The aim of this study was to examine the direct and indirect effects of antenatal exposures to these risks and infant motor development. METHODS A cohort of women who were pregnant with a single foetus and between 12 and 20 weeks pregnant in 50 randomly-selected r...

ue to obvious ethical issues of experimenting drugs during fetal development, women and their unborn babies are commonly excluded from drug trials. As a result, these two groups of patients are commonly orphaned from the revolution in drug therapy witnessed in the last generation. The removal of Bendectin from the American market despite being safe in pregnancy sent a chilling signal to drug co...

QUESTION In light of recent negative media attention to antidepressant use during late pregnancy, several of my patients have either discontinued or are considering discontinuing their antidepressant medications. How can I best counsel these patients on taking antidepressants during late pregnancy? ANSWER Antidepressant use during the third trimester has been associated occasionally with a tr...