The amino acid substitution Arg72Pro in the TP53 protein has an impact on the biochemical and biological activity of this protein, and is associated with several types of cancers. However, the Arg72Pro polymorphism exhibits inconsistent contribution as a risk factor in various cancer types. Therefore, using PCR-RFLPs, we investigated the distribution of Arg72Pro genotypes and alleles in patient...

Determining the standard of care for a cancer with a diverse set of treatment variables is difficult. Advanced laryngeal cancer is one such case. The treatment for advanced laryngeal cancer is now at a point where the current standard of care—concurrent chemotherapy and radiotherapy with surgical salvage (ie, laryngectomy)—must be reexamined. Why? Because published studies—identified as evidenc...

Human esophageal cancer‑related gene 4 (ECRG4) is a potential tumor suppressor gene isolated from human esophageal epithelial cells. Studies have shown that ECRG4 effectively inhibits the proliferation of tumor cells and induces apoptosis. However, the role of ECRG4 in laryngeal cancer has not yet been clearly defined. In this study, a human laryngeal cancer cell line stably overexpressing ECRG...

The risk factors affecting the survival rates of laryngeal carcinoma are not well understood. In this study, we investigated the expression status of mutS homolog 2 (MSH2) and mutL homolog 1 (MLH1) and examined the relationship between these two molecules and overall survival rates in laryngeal cancer. We also explored the potential reason for the altered expression of these two genes. Using re...

The airway is not only shared but operated upon during laryngeal cancer surgery. Patients with laryngeal cancer may require general anesthesia for diagnostic endoscopic procedures, for endolaryngeal laser surgery or for major cancer resectional surgery. This review outlines the importance of careful assessment of the airway and medical comorbidities and discusses the options for anesthetic and ...

Preservation of the larynx is the most critical factor influencing quality of life in the treatment of head and neck cancer. This clinical study focuses on laryngeal function-preserving chemoradiotherapy for locally advanced hypopharyngeal and laryngeal cancer. Thirty-two resectable cases with histologically proven squamous cell carcinoma undergoing function-preserving therapy were examined. In...

After a steady increase since the 1950s, laryngeal cancer mortality had tended to level off since the early 1980s in men from most European countries. To update trends in laryngeal cancer mortality in Europe, age-standardized (world standard) mortality rates per 100,000 were derived from the WHO mortality database for 33 European countries over the period 1980-2001. Jointpoint analysis was used...

Background Till not many years ago, the recommended treatment for advanced laryngeal cancer was a total laryngectomy followed by adjuvant radiation therapy. Studies conducted from 1980’s have broadened the therapeutic options, in the attempt to cure the cancer while sparing laryngeal functions. Functional surgery and a combination of chemotherapy (CT) and radiotherapy (RT) appears to be able to...

17β-estradiol (E2) plays a key role in tumorigenesis by enhancing cell survivability and metastasis through its cytoplasmic receptors. Recently, a variant of estrogen receptor alpha, ERα36 has been implicated as a substantial mediator of E2's proliferative and antiapoptotic effects through rapid membrane-associated signaling, and cancers previously regarded as hormone-independent due to the abs...

A previous study indicated that MLL3 genetic polymorphisms were associated with human cancer. However, whether MLL3 genetic variants are associated with the risk of laryngeal cancer is not clear. This study investigated the association between MLL3 gene polymorphisms and laryngeal cancer in a Chinese population. Four polymorphisms of the MLL3 gene (rs6943984, rs4725443, rs3800836, rs6464211) we...