To determine whether increased migration is associated with an increase in incidence of toxocariasis (visceral larva migrans), we analyzed clinical data obtained from immigrants from Latin America. Although infection with Toxocara sp. roundworm larvae is distributed worldwide, seroprevalence is highest in tropical and subtropical areas.

objective(s) considering fair response to inhaled corticosteroids and reports of severe air way hyper responsiveness in chemical warfare victims (cwv), a role for eosinophilic inflammation (i.e. asthma) was postulated. the objective of this study was to determine the presence of eosinophilic inflammation in cwv by evaluation of sputum cellularity and eosinophil cationic protein (ecp). materials...

Blood eosinophilia and tissue infiltration by eosinophils are frequently observed in allergic inflammation and parasitic infections. This selective accumulation of eosinophils suggested the existence of endogenous eosinophil-selective chemoattractants. We have discovered a novel eosinophil-selective chemoattractant which we called eotaxin in an animal model of allergic airways disease. Eotaxin ...

The selective accumulation of eosinophils in tissue is a characteristic feature of allergic diseases where there is a predominance of lymphocytes expressing a Th2 phenotype. In an attempt to define factors determining specific eosinophil accumulation in vivo, we have used a radiolabeled technique to assess the occurrence and the mechanisms underlying (111)In-eosinophil recruitment into Th1- and...

Gnathostomosis has been known since 1836, when the parasite was discovered in the stomach of a tiger in London Zoo. Today it is considered an important food-borne parasitic zoonosis, endemic mainly in Asian countries where some people prefer to eat raw fish, amphibians or reptiles. In its mammal definitive host the adults are located in the stomach wall, even in granulomes. The eggs leave the d...

Introduction: Human Toxocariasis is a zoonotic helminthic infection caused by migration of larval stage of Toxocara canis and Toxocara catti (T.canis and T.catti) that mainly affects children. The purpose of this study was to evaluate the frequency of anti-Toxocara antibody IgG in serums of 5-15-years-old children referred to Bandar Abbas and rural parts of nearby health centers. Along with Ant...

Leukotriene B4 (LTB4) is a chemotactic and cell-activating factor present at inflammatory sites in a variety of autoimmune diseases including multiple sclerosis (MS). In this study, we used a murine model of MS, experimental allergic encephalomyelitis (EAE), to assess the potential role of LTB4 on cell infiltration and paralysis. Injection of encephalogenic T cells into naive animals induced pa...

The priming of eosinophils by cytokines leading to augmented response to chemoattractants and degranulating stimuli is a characteristic feature of eosinophils in the course of allergic inflammation and asthma. Actin reorganization and integrin activation are implicated in eosinophil priming by GM-CSF, but their molecular mechanism of action is unknown. In this regard, we investigated the role o...

Eosinophil arrest and recruitment to the airway in asthma are mediated, at least in part, by integrins. Eosinophils express α4β1, α6β1, αLβ2, αMβ2, αXβ2, αDβ2, and α4β7 integrins, which interact with counter-receptors on other cells or ligands in the extracellular matrix. Whether a given integrin-ligand pair mediates cell adhesion and migration depends on the activation state of the integrin. I...