An experiment by Tversky and Kahneman (1981) illustrates that people's tendency to evaluate risky decisions separately can lead them to choose combinations of choices that are …rst-order stochastically dominated by other available combinations. We investigate the generality of this e¤ect both theoretically and experimentally. We show that for any decisionmaker who does not have constant-absolut...

The US Food and Drug Administration (FDA) has recently suggested that the bioequivalence (BE) for products of drugs with narrow therapeutic indices (NTI) be assessed by the approach of reference-scaled average BE (SABE). Subsequently, in December, 2012, the FDA issued draft guidances for the comparison of products of warfarin sodium and of tacrolimus. The guidances expect that 4-period studies ...

BACKGROUND Detection of early recurrent nasopharyngeal carcinoma (NPC) is clinically challenging. Narrow-band imaging (NBI) is powerful in detecting early superficial lesions in the head and neck, although the utility of NBI in detecting nasopharyngeal cancer is still unknown. METHODS AND RESULTS We describe a case of a 51-year-old man with early recurrent NPC detected in subclinical stage by...

Introduction: Development of higher energy modalities such as positron emission tomography/computed tomography (PET/CT), has led to more complex shielding problems. This is due to several factors, such as the radiopharmaceutical relatively high-administered activity, high patient throughput, and high energies of 511 kilo-electron volt (keV) positron annihilation photon...