نتایج جستجو برای: l929 cell

تعداد نتایج: 1684380  

2017
Ping Ouyang Sen Wang He Zhang Zhigang Huang Pei Wei Ye Zhang Zhuguo Wu Tao Li

Leptin and hypoxia are pro-fibrotic factors involved in fibrogenesis, however, the gene expression profiles remain to be fully elucidated. The aim of the present study was to investigate the regulatory roles of leptin and hypoxia on the L929 mouse fibroblast cell line. The cells were assigned to a normoxia, normoxia with leptin, hypoxia, and hypoxia with leptin group. The cDNA expression was de...

Journal: :Hacettepe Journal of Biology and Chemistry 2021

The aim of this in vitro study was assessment the cytotoxic level 6-O-desmethylnaproxen. A mouse connective tissue fibroblast cell line, L929 exposed to naproxen and 6-O-desmethylnaproxen different concentrations for 24- 48- hours. Cell viability tested by MTT, while apoptosis determined AO/PI double staining method. control group free from any agent (DMEM only) accepted as 100% viability. IC50...

2017
R. Mary Suja B. Christudhas Williams

The main objective of the present investigation is to evaluate the phytochemical constituents, cytotoxic and antiproliferative effect of Karumsurathi Thailam prescribed by the Traditional Siddha Practitioner of Kanyakumari District, India. The external form of Breast Cancer medicine prescribed above 18 years was prepared with 18 different plant ingredients. Phytochemical analysis of the Thailam...

Journal: :European journal of medicinal chemistry 2006
Mathieu Sassatelli Eric Debiton Bettina Aboab Michelle Prudhomme Pascale Moreau

A convenient synthesis of indolin-2-ones substituted in the 3 position by an aminomethylene group bearing different amino acid moieties is described. Their antiproliferative activities were evaluated toward a panel of human solid tumor cell lines (PC 3, DLD-1, MCF-7, M4 Beu, A549, PA 1) and healthy cell lines (a murine fibroblast L929 and a human fibroblast primary culture).

Journal: :Biochimica et biophysica acta 2006
Etsu Kishida Michiko Tajiri Yasuo Masuzawa

We previously reported that docosahexaenoic acid (DHA) attenuated tumor necrosis factor (TNF)-induced apoptosis in human monocytic U937 cells (J. Nutr. 130: 1095-1101, 2000). In the present study, we examined the effects of DHA and other polyunsaturated fatty acids (PUFA) on TNF-induced necrosis, another mode of cell death, using L929 murine fibrosarcoma cells. After preincubation with PUFA con...

Journal: :Indian journal of experimental biology 2010
Vinoth S Ravindran L Kannan K Venkateshvaran

Potent cytolytic activity was exhibited by proteins extracted from three sea anemones viz. Heteractis magnifica, Stichodactyla haddoni and Paracodylactis sinensis by affecting the red blood corpuscles (RBC) and the mouse fibroblast cell line (L929) and leukemia cell line (P388). Crude toxin of all the three anemone species induced spontaneous hemolysis of chicken, goat and human erythrocytes. T...

Journal: :Toxicology in vitro : an international journal published in association with BIBRA 2011
Viviana R Lopes Michaela Schmidtke M Helena Fernandes Rosário Martins Vitor Vasconcelos

The cyanobacteria are known to be a rich source of metabolites with a variety of biological activities in different biological systems. In the present work, the bioactivity of aqueous and organic (methanolic and hexane) crude extracts of cyanobacteria isolated from estuarine ecosystems was studied using different bioassays. The assessment of DNA damage on the SOS gene repair region of mutant PQ...

Background and purpose: Cancer is one of the major health challenges in the world. The efficacy of current treatments is low but their side effects are high. Cold atmospheric plasma (CAP) is a new modality for cancer treatment. This study aimed to compare the cytotoxicity effect of CAP on the cell line models of common cancers and normal cells. Materials and methods: In this experimental study...

2014
Yuqing Jiang Qinghua Zheng Xuedong Zhou Yuan Gao Dingming Huang

Cytocompatibility of repair materials plays a significant role in the success of root canal repair. We conducted a comparative study on the cytocompatibility among iRoot BP Plus, iRoot FS, ProRoot MTA, and Super-EBA in L929 cells and MG63 cells. The results revealed that iRoot FS was able to completely solidify within 1 hour. iRoot BP Plus required 7-day incubation, which was much longer than e...

2006
Teruhiro Utsugi Michael R. Mattern Christopher K. Mirabelli Nabil Hanna

A combination of tumor necrosis factor (INI) and the topoisomerase I inhibitor, camptothecin, or the topoisomerase II inhibitors, teniposide and amsacrine, produced dose-dependent synergistic cytotoxicity against the murine L929 fibrosarcoma cells. Similar synergy was not observed with a combination of TNF and bleomycin. To define the role of TNF in the augmentation of tumor cell killing by top...

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