l-Histidine and, to a lesser degree, l-phenylalanine at concentrations of 10(-4)m inhibit the growth of leaky mutants (bradytrophs) of Bacillus subtilis that are deficient in the synthesis of p-hydroxyphenylpyruvate, the first intermediate specific to tyrosine synthesis. The inhibition can be overcome by growth factor amounts of l-tyrosine and p-hydroxyphenylpyruvate. Histidine and phenylalanin...

background :according to numerous studies, fms-like tyrosine kinase 3, internal tandem duplication, and the d835 mutation are associated with a poor prognostic clinical outcome in acute myeloid leukemia patients. detection of the fms-like tyrosine kinase 3 mutation in patients who present with normal karyotype acute myeloid leukemia helps in both the understanding of the disease and the treatme...

The soft X-ray absorption spectroscopy (XAS) spectra of Alanine, L- and D-phenylalanine, D-tyrosine dissolved in a solid state were measured at BL17SU SPring-8. exhibited characteristic features dependent on the molecular structure. It was found that almost same obtained for Alanine Phenylalanine, while Tyrosine, spectral shape indicated drastic change owing to existence oxygen 1s → π* transiti...

Non-natural amino acids have been genetically encoded in living cells, using aminoacyl-tRNA synthetase-tRNA pairs orthogonal to the host translation system. In the present study, we engineered Escherichia coli cells with a translation system orthogonal to the E. coli tyrosyl-tRNA synthetase (TyrRS)-tRNA(Tyr) pair, to use E. coli TyrRS variants for non-natural amino acids in the cells without in...

Djungarian hamster (P. sungorus) and Roborovskii hamster (P. roborovskii) belong to the same genus of phodopus. Roborovskii hamster shows high locomotor activity and low level of dopamine (DA) in the brain. Administration of L-tyrosine, a precursor of DA, decreases locomotor activity in Roborovskii hamsters. However, the amino acid metabolism in relation to the hyperactivity is not yet well kno...

The experiments of Sealock et al. (l-3) and of Levine et al. (4) have given reasons for believing that one of the functions of ascorbic acid in the animal body is to facilitate the metabolism of L-tyrosine and L-phenylalanine. Sealock and Silberstein (2) showed that the administration of tyrosine orally to scorbutic guinea pigs resulted in the excretion of metabolites containing the benzene rin...

The d-isomer of tyrosine is a potent inhibitor of growth in transformable strain 168 of Bacillus subtilis. A d-tyrosine-resistant mutant of the inhibited strain was isolated which excreted l-tyrosine, had a diminished growth rate, and required l-phenylalanine to attain the growth rate of the wild-type parent. Mapping by deoxyribonucleate transformation located this resistance in the gene coding...

BACKGROUND The 3,4-dihydroxy phenyl L-alanine (L-dopa) is a drug of choice for Parkinson's disease, controlling changes in energy metabolism enzymes of the myocardium following neurogenic injury. Aspergillus oryzae is commonly used for L-dopa production; however, potential improvements in ease of handling, growth rate and environmental impact have led to an interest in exploiting alternative ye...

Punch, J. D. (University of Minnesota, St. Paul), J. C. Olson, Jr., and J. V. Scaletti. Amino acid utilization by Alcaligenes viscolactis for growth and slime production. J. Bacteriol. 89:1521-1525. 1965.-The ability of Alcaligenes viscolactis to utilize amino acids in a basal salts solution (K(2)HPO(4), KH(2)PO(4), MgSO(4), MnSO(4), FeSO(4), NaCl) was studied. Of 27 amino acids, only l-asparag...