Metabolism of tamoxifen by rat and human hepatic microsomal cytochrome P450s (CYPs) forms a reactive intermediate that irreversibly binds to microsomal proteins (C. Mani and D. Kupfer, Cancer Res., 51: 6052-6058, 1991.). The current study examines the nature of the tamoxifen metabolite that is proximate to the reactive intermediate(s). The rate of covalent binding of tamoxifen metabolites, tamo...

In order to determine the organ specific carcinogenicity of benzo(a)pyrene (B(a)P), its metabolites, formed in vitro by incubation with the homogenates from liver, lungs, kidneys, intestine and brain of rats, were isolated by TLC and spectroscopy. B(a)P was found to be converted into a number of metabolites by different tissue homogenates. The results showed that the proximate carcinogenic meta...

The walking and surface film locomotion of a terrestrial spider, Lycosa rabida Walckenaer, and a semi-aquatic spider, Dolomedes triton (Walckenaer), are compared. Stepping patterns during locomotion on a solid substrate resemble an alternating tetrapod in both species. L. rabida retains elements of the terrestrial gait when moving on water: propulsive thrusts are concentrated at the tarsi and i...

The aim of this study was to determine the meat quality characteristics of young and spent quail meats. Young quail meat (age 8 week ± 3 days) and spent quail meat (age 8 month ± 3 days) were used in this experiment. Comparison of the proximate compositions, pH, colour, and fatty acid of quail meats showed significant differences (p<0.05). The young quail meat had significantly higher moisture,...

Although distributed Group Support Systems (GSS) are getting popular, there are still some limitations. One of the limitations is few substitutions for face-to-face (FTF) interaction (whether it is related to meeting content or not), so we may say that FTF interaction is one of the advantages of proximate types of GSS. However, there are few studies that focus only on the role of FTF interactio...