ROSENTHAL, J., A. ANGEL, AND J. FARKAS. Metabolic fate of leucine: a sign$kant sterol precursor in adipose tissue and muscle. Am. J. Physiol. 226(2) : 411-418. 1974.-The quantitative significance of muscle and adipose tissue as extrahepatic sites of leucine metabolism was studied. The rate of leucine conversion to either CO* or total lipid expressed per gram wet weight of tissue was adipose tis...

The ability of the SLC6 family members, the insect neutral amino acid cotransporter KAAT1(K(+)-coupled amino acid transporter 1) and its homologous CAATCH1(cation anion activated amino acid transporter/channel), to transport D-amino acids has been investigated through heterologous expression in Xenopus laevis oocytes and electrophysiological techniques. In the presence of D-isomers of leucine, ...

There have been many published accounts of idiopathic leucine-sensitive hypoglycaemia of infancy since its description by Cochrane, Payne, Simpkiss, and Woolf in 1956, and raised plasmainsulin levels after the administration of L-leucine have been found in children with this condition (DiGeorge, Auerbach, and Mabry, 1960; Grumbach and Kaplan, 1960; Harmer and Sinclair, 1964). Similar changes in...

Membrane vesicles of Leuconostoc mesenteroides subsp. dextranicum fused with proteoliposomes prepared from Escherichia coli phospholipids containing beef heart cytochrome c oxidase were used to study the transport of branched-chain amino acids in a strain isolated from a raw milk cheese. At a medium pH of 6.0, oxidation of an electron donor system comprising ascorbate, N,N,N',N'-tetramethyl-p-p...

The binding interactions of cucurbit[8]uril (Q[8]) with l -valine, d -leucine, and -methionine, both in aqueous solution solid state, have been studied by 1 H NMR spectroscopy X-ray crystallography.

A series of copolymers of L-leucine and/3-benzyI-L-aspartate [Leu/Asp(OBz)] covering the range 30-70 mol % of L-leucine, was synthesized by the N-carboxyanhydride (NCA) method. The copolymers were characterized by elemental analysis, infra-red spectroscopy and viscometry. For all compositions high molecular weight copolymers were prepared with excellent film-forming properties. Tercopolymers of...

BACKGROUND Leucine has been suggested to improve athletic performance. Therefore, the branched-chain amino acids (BCAAs), especially leucine, are popular as dietary supplements in strength-training athletes; however, the intake of leucine in excess of requirements raises concerns regarding adverse effects. Currently, the tolerable upper intake level (UL) for leucine is unknown. OBJECTIVE The ...

Two new compounds, 4S,10R-dihydroxy-11-methyl-dodec-2-en-1,4-olide (1) (butyrolactone-type) and cyclo-(4-trans-6-dihydroxy-proline-D-leucine) (2) (diketopiperazine-type), as well as one known 4S,10-dihydroxy-10-methyl-dodec-2-en-1,4-olide (3) and three known diketopiperazines, cyclo-(L-proline-L-leucine) (4), cyclo-(4-trans-hydroxy-L-proline-L-leucine) (5), and cyclo-(4-trans-hydroxy-L-proline-...

The aim of the present study was to evaluate the effect of leucine treatment (0.30 mM) on muscle weight and signaling of myoproteins related to synthesis and degradation pathways of soleus muscle following seven days of complete sciatic nerve lesion. Wistar rats (n = 24) of 3-4 months of age (192 ± 23 g) were used. The animals were randomly distributed into four experimental groups (n = 6/group...