OBJECTIVES Glutathione S-transferase (GST) A1 catalyses the activated heterocyclic aromatic a mine carcinogenN-acetoxy-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OAc-PhIP). This case-control study was carried out to examine whether the genetic polymorphism of GSTA1 is associated with the risk oforal squamous cell carcinoma among Japanese people in relation to their smoking status. MET...

Head and neck squamous cell carcinoma and especially oropharyngeal squamous cell carcinoma is a very significant cause of morbidity and mortality. The majors risk factors of these tumors are tobacco smoking, chewing and alcohol consumption. But there is a group, non-drinking and non-smoking, patients with oropharyngeal squamous cell carcinoma. In these patients may be oral-genital contact and h...

OBJECTIVE To analyze the genetic polymorphisms of the cytochrome P450 family and their relationship with squamous cell carcinoma of the oral cavity, pharynx and larynx. METHODS We present a narrative literature review, conducted in PubMed, Lilacs and Cochrane Databases of articles published in the last five years correlating genetic polymorphisms of the cytochrome P450 family and cancer risk ...

Objective: To analyze the genetic polymorphisms of the cytochrome P450 family and their relationship with squamous cell carcinoma of the oral cavity, pharynx and larynx. Methods: We present a narrative literature review, conducted in Pubmed, Lilacs and Cochrane Databases of articles published in the last five years correlating genetic polymorphisms of the cytochrome P450 family and cancer risk ...

background: although color doppler ultrasonography (cdus) is useful in the diagnosis of various diseases of the head and neck, flow signals in oral malignant masses are less studied; hence the present study assesses the usefulness of color doppler ultrasonography in quantifying oral squamous cell carcinoma (oscc) vascularization. in addition, we determine the hemodynamic parameters by spectral ...

Background: Oral cancer represents a significant component of the global burden. It develops as result multiple risk factors. The main histological form oral is squamous cell carcinoma (OSCC). disintegration extracellular matrix (ECM) one key hallmarks progression, which stimulates invasion tumoral cells into neighbouring tissue. Matrix metalloproteinases-9 (MMP-9) can degrade different element...

introduction: a rare case of basaloid squamous cell carcinoma (bscc) of the larynx, which has not been previously reported, is described. case report: a 60-year-old man was presented to the otolaryngology department with progressive dyspnoea and dysphagia to solids for over a period of 1 week. direct laryngoscopy revealed a tumour at the laryngeal aspect of the epiglottis, which prolapsed into ...

Since the early 1970s, the incidence of oesophageal adenocarcinoma has increased dramatically in most Western populations. In contrast, the incidence of oesophageal squamous-cell carcinoma has decreased in these same populations. Epidemiological studies conducted over the past decade have provided great insights into the etiology of oesophageal cancer. These studies have identified gastro-oesop...

Oral squamous cell carcinoma is an important malignancy of epithelial origin with high rate of morbidity and mortality. While tobacco and alcohol are the primary risk factors; other factors such as microorganisms, chronic irritation and sex hormones along with underlying genetic factors may also contribute to its pathogenesis. The role of sex hormones like estrogen, progesterone and testosteron...

Introduction: Regarding the lack of data on the  frequency of oral cancer in Babol, the aim of this study was to evaluate the frequency of oral cancer in Babol during 2012-2016. Material & Methods: This retrospective cross-sectional study was performed using pathology sheet records of oral cancer patients during 2012-2016. Survival status of patients was collected through telephone contact. R...