Culture has long been assumed to be uniquely human but recent studies, in particular on great apes, have suggested that cultures also occur in non-human primates. The most apparent cultural behaviours in great apes involve tools in the subsistence context where they are clearly functional to obtain valued food. On the other hand, tool-use to modify acoustic communication has been reported only ...

Two studies demonstrate that a dispositional proneness to disgust ("disgust sensitivity") is associated with intuitive disapproval of gay people. Study 1 was based on previous research showing that people are more likely to describe a behavior as intentional when they see it as morally wrong (see Knobe, 2006, for a review). As predicted, the more disgust sensitive participants were, the more li...

Kisspeptin and its receptor, GPR54, play important roles in mammalian reproduction and cancer development. However, little is known about their function in nonmammalian species. In the present study, we have isolated the cDNA encoding the kisspeptin receptor, GPR54, from the bullfrog, Rana catesbeiana. The bullfrog GPR54 (bfGPR54) cDNA encodes a 379-amino acid heptahelical G protein-coupled rec...

Guanine nucleotide binding protein (G-protein)-coupled receptors (GPCRs) are eukaryotic transmembrane proteins found in all living organisms. Their versatility and roles in several physiological processes make them the single largest family of drug targets. Comparative genomic studies using various model organisms have provided useful information about target receptors. The similarity of the ge...

Cancer disease is the second leading cause of death in the world and one of the main fields of medical research. Although there is now a greater understanding of biological mechanisms of uncontrolled cell growth, invasiveness and metastasization, the multistep process of cancer development and evolution is still incompletely understood. The inhibition of molecules activated in cancer metastasiz...

Abstract Purpose To find the expression of KISS-1 and G protein-coupled receptor 54 in rats testis from PND 21st to 56th. Method 128 three-week-old weaned underwent high-fat diet exercise (60–70% VO 2max , 1 h/day, 5 days/week) intervention were randomly divided into group C, CE, HC, or HE. Sample time points set on 21st, 35th, 43rd, The testicular testosterone mRNA content, protein content GPR...

Unfortunately, the extensive use of weight based cost estimating relationships has generated a perception in the aerospace community that the primary way to reduce cost is to reduce weight. Wrong! Based upon an approximation of an industry accepted formula, the PRICE H [1] production-production equation, Dean [7] demonstrated theoretically that the optimal trajectory for cost reduction is pred...