Integrin-mediated cell-ECM (extracellular matrix) adhesion is a fundamental process that controls cell behaviour. For correct cell-ECM adhesion, both the ligand-binding affinity and the spatial organization of integrins must be precisely controlled; how integrins are regulated, however, is not completely understood. Kindlins constitute a family of evolutionarily conserved cytoplasmic components...

BACKGROUND Epidermolysis bullosa (EB) is a genodermatosis caused by mutations in the proteins of dermal-epidermal junction, altering epithelial cohesion, and generating blisters shedding skin mucous membranes. OBJECTIVE To describe demographic clinical characteristics, as well main complications patients with EB attended at National Institute Pediatrics, Mexico City. METHOD An observational, de...

Robert Bartlett, Die Geburt Europas aus dem Geist der Gewalt. Eroberung, Kolonisierung und kultureller Wandel von 950 bis 1350, München (Kindler) 1996, 509 S.

Germany officially the Federal Republic of Germany, is of the European conuntries. With 81.8 million inhabitants, it is the most populous member state in the European Union. It is one of the major political and economic powers of the European continent and a historic leader in many theoretical and technical fields [1]. The country has developed a very high standard of living and features a comp...