نتایج جستجو برای: kidney injury molecule 1

تعداد نتایج: 3210891  

Journal: :The Journal of clinical investigation 2013
Benjamin D Humphreys Fengfeng Xu Venkata Sabbisetti Ivica Grgic Said Movahedi Naini Ningning Wang Guochun Chen Sheng Xiao Dhruti Patel Joel M Henderson Takaharu Ichimura Shan Mou Savuth Soeung Andrew P McMahon Vijay K Kuchroo Joseph V Bonventre

Acute kidney injury predisposes patients to the development of both chronic kidney disease and end-stage renal failure, but the molecular details underlying this important clinical association remain obscure. We report that kidney injury molecule-1 (KIM-1), an epithelial phosphatidylserine receptor expressed transiently after acute injury and chronically in fibrotic renal disease, promotes kidn...

Journal: :Toxicological sciences : an official journal of the Society of Toxicology 2008
Yuzhao Zhou Vishal S Vaidya Ronald P Brown Jun Zhang Barry A Rosenzweig Karol L Thompson Terry J Miller Joseph V Bonventre Peter L Goering

Sensitive biomarkers are needed to detect kidney injury at the earliest stages. The objective of this study was to determine whether the appearance of kidney injury molecule-1 (Kim-1) protein ectodomain in urine and kidney injury molecule-1/hepatitis A viral cellular receptor-1 (Kim-1/Havcr1) gene expression in kidney tissue may be more predictive of renal injury after exposure to nephrotoxican...

Journal: :Biochemical and Biophysical Research Communications 2021

The relationship between cellular senescence and fibrosis in the kidney is being elucidated we have identified it as therapeutic target recent studies. Chronic disease has also become a lifestyle disease, often developing on background of hypertension dyslipidemia. In this study, clarify effect interaction these two conditions senescence. Wild type mice (WT), apolipoprotein E-/- (ApoEKO), endot...

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