In response to ionizing radiation, p53 plays a critical role in regulating DNA repair and apoptosis. Among multiple phosphorylation sites, evidence suggests that Ser46 promotes apoptotic cell death through mitochondrial outer membrane permeabilization (MOMP) and subsequent activation of the caspase 7-PARP pathway. Therefore, we investigated which phosphatase regulates Ser46 after ionizing radia...

Introduction: Unwanted exposure of ionizing radiation may result in carcinogenesis, cell mutations, and organ failure. High-atomic number elements such as lead, tungsten, bismuth have been traditionally used for radiation protection. Theoretical and practical studies have shown that a variety of shielding materials e.g. polymer composites (PCs) can be used for attenuation of th...

Background: The fatal effect of ionizing radiation on cells depends on Linear Energy Transfer (LET) level. The distribution of ionizing radiation is sparse and homogeneous for low LET radiations such as X or γ, but it is dense and concentrated for high LET radiation such as heavy-ions radiation. Material and Methods: Chinese hamster ovary cells (CHO-K1) were exposed to 4 Gy Fe-ion 2000 keV/...

Ionizing and non-ionizing electromagnetic field (EMF) radiation, either stand-alone or in combination with other agents, exert health effects on biological systems. The present chapter examines the scope of non-ionizing EMF radiation combined effects; i.e., identifies effects on biological systems from combined exposure to non-ionizing electromagnetic fields/radiation and at least one other age...

introduction: occupational exposure to ionizing radiation due to medical activities (both diagnostic and therapeutic procedures) has increased sharply in recent years. among the occupationally exposed workers in these fields, those most affected by this increased exposure to ionizing radiation are nuclear medicine workers. in this study, annual average effective dose, annual collective effectiv...