mitochondrial myopathy, lactic acidosis, and sideroblastic anemia (mlasa) syndrome is a rare autosomal recessive disorder of oxidative phosphorylation and iron metabolism. the association between myopathy and sideroblastic anemia was initially reported in 1974. here we report an 8.5 year old boy with normal cognitive function, suffering from chronic progressive weakness in his lower extremities...

The transition from normal forage to a highly fermentable diet to achieve rapid weight gain in the cattle industry can induce ruminal acidosis. The molecular host mechanisms that occur in acidosis are largely unknown. Therefore, the histology and transcriptome profiling of rumen epithelium was investigated in normal and acidosis animals to understand the molecular mechanisms involved in the dis...

Ten years male patient known case of Type 1 diabetes mellitus presented in diabetic keto acidosis (DKA) with history of sudden onset right ocular swelling progressing to complete loss of eye movements with ptosis over 5 days. There was associated history of fever, mild to moderate grade along with vomiting and decreased visual acuity. Patient left insulin for 1 day because of vomiting that lead...

Palladium (II) coordination complexes catalyze the reaction of alcohols with ketones to yield ethers. During the catalytic cycle, the alcohol adds selectively to the β-carbon (anti-Markovnikov). In this work, mechanism and kinetics for the reaction of methanol with methyl vinyl ketone (MVK), being catalyzed by Pd, has been theoretically investigated in detail. Using quantum mechanical approach,...

The effect of the long chain keto acid, which is one of the secondary products from oxidative deteriolation of lipids, on the enzyme activity was investigated in vitro. Cholinesterase and succinate dehydrogenase were inhibited more effectively by 12-keto oleic acid than by linoleic acid, whereas the inhibition of trypsin by linoleic acid was greater than that caused by 12-keto oleic acid. This ...

By oxidation of P-keto acids, cyclopropanols, and acyl chromate complexes with tris(2-pyridinecarboxylato)manganese(III) (Mn(pic)g), a-keto, p-keto, and alkyl radicals are generated respectively, which react with olefinic compounds to afford intermolecular addition products in good yield. The cation radicals can be generated from a-stannylalkyl sulfides, (1 -stannylalkyl)amino compounds, and a-...

background:poisoning with ethylene glycol (eg) can be fatal even if appropriate treatments are delivered. eg poisoning usually causes central nervous system depression, cardiovascular dysfunction, metabolic acidosis and acute renal failure (arf). case report:a 33-year-old man was referred to the emergency department with reduced consciousness and dyspnea of four-hour duration due to unknown rea...

effects of acute hypercapnia on the cardiovascular system (cys) were studied in the anesthetized cat. after surgery the animal was exposed to a gas mixture of 12% co2 and 25% o2 in nitrogen, and hypercapnia with low levels of arterial ph (pha) was produced for 20 minutes. in the second run the same level of hypercapnia was induced by ventilating the same cat from the above gas mixture but pha w...

a case of renal tubular acidosis (rta) who had gradual onset of paralysis of lower extremities and persisted for a long time is presented. his primary workups were mistaken for muscular dystrophy. eventually, an abdominal ultrasonography revealed small stones in both of the kidneys and his workup for the stones were in favor of distal renal tubular acidosis and advanced rickets with hypokalemia...