PURPOSE To determine the corneal elevation values and keratoconus indices in the 40- to 64-year-old population and their changes with aging. METHODS The 6311 invitees of this study were selected through random cluster sampling, and 5190 of them participated in the study (response rate = 82.2%). Here, we analyzed results of Pentacam acquisitions in 4148 respondents. Cases of keratoconus and fo...

Isolated photophores of Porichthys notatus, maintained in saline at 20 degrees C, do not luminesce and show an oxygen consumption rate of 0.07 +/- 0.01 nmol min-1 photophore-1. In the presence of 10(-6) M-KCN, the photophores do not luminesce but the resting respiration decreases by about 50%. In the presence of 10(-5) M-KCN, some photophores do not luminesce and their respiration rate decrease...

AIMS To examine histopathological and immunohistochemical changes in lenticules and host of corneal buttons from patients who previously underwent epikeratoplasty for keratoconus. METHODS 12 penetrating keratoplasty specimens from patients with keratoconus who had previously undergone epikeratoplasty, eight keratoconus, and seven normal corneas were examined. Immunostaining for Sp1, alpha1-pr...

AIM To compare the performance of keratoconus, penetrating keratoplasty (PK), and control subjects on clinical tests of contrast and glare vision, to determine whether differences in vision were independent of visual acuity (VA), and thereby establish which vision tests are the most useful for outcome studies of PK for keratoconus. METHODS All PK subjects had keratoconus before grafting and n...

Endogenous coupled respiration of Micrococcus luteus protoplasts showed a relatively high resistance to low concentrations of KCN, 2-nonyl-4-hydroxyquinoline N-oxide (NQNO) and dicyclohexylcarbodi-imide (DCCD) when the inhibitors were applied individually. In the presence of both KCN and NQNO (or DCCD), O2 uptake was strongly inhibited. The proteolysis of external membrane proteins of protoplas...

Keratoconus is the most common ectatic disorder of the corneal. Genetic and environmental factors may contribute to its pathogenesis. The focus of this article is to summarize current research into the complex genetics of keratoconus. We discuss the evidence of genetic etiology including family-based linkage studies, twin studies, genetic mutations, and genome-wide association studies. The gene...

Objective: To compare Corvis ST (Oculus Wetzlar, Germany) and Pentacam (Oculus) derived indices to detect normal cornea, keratoconus for mefruste keratoconus.
 Study Design: Comparative cross sectional study.
 Place Duration of Study: Armed Forces Institute Ophthalmology (AFIO), Rawalpindi, from Feb Jul 2019.
 Methodology: Following strict inclusion criteria 90 patients were enro...

PURPOSE To formulate and test an algorithm using minimal topographic criteria for accurately diagnosing clinical keratoconus. SETTING Subspecialty cornea practice and Keratoconus Genetic Research Project. METHODS Both eyes of 86 keratoconic patients who had never worn contact lenses and 195 normal participants were studied with the TMS-1 videokeratoscope to evaluate the KISA% index, an algo...

PURPOSE Keratoconus is a bilateral noninflammatory progressive corneal disorder with complex genetic inheritance and a common cause for cornea transplantation in young adults. A genomewide linkage scan in keratoconus families identified a locus at 5q23.2, overlapping the gene coding for the lysyl oxidase (LOX). LOX encodes an enzyme responsible for collagen cross-linking in a variety of tissues...

PURPOSE To investigate the neuroprotective effects of brain-derived neurotrophic factor (BDNF) against potassium cyanide (KCN)-induced retinal damage. METHODS Rats were injected intravitreally with iodinated BDNF. Two days later, eyeballs were dissected into various parts, and the level of radioactivity in each part was measured. Retinal damage was induced by incubating rat eyeballs with 5 mM...