CONTEXT One of the major current challenges related to juvenile idiopathic inflammatory myopathy is the search for highly sensitive and specific non-invasive methods for diagnosis as well as for follow-up. OBJECTIVES The aim of our study was to describe typical magnetic resonance imaging findings and to investigate the usefulness of this method in detecting active muscle disease in juvenile d...

Results More than 4000 determinations of ferritin requested by the study unit were performed between January 2004 and December 2007 by the central laboratory of the study hospital. Hyperferritinemia was found in 408 determinations in 87 patients. The most common specific diagnoses in patients with hyperferritinemia were the following: systemic juvenile idiopathic arthritis (sJIA) (48.3%), syste...

OBJECTIVE Spirometric evaluation in juvenile systemic lupus erythematosus. METHODS Forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), FEV1/FVC, forced expiratory flow between 25-75% of vital capacity (FEF25-75%) and peak expiratory flow rate (PEFR) of 21 patients with juvenile SLE (jSLE) were compared to controls. RESULTS Reduced FVC and FEF25-75% was found in 18 and ...

OBJECTIVE To determine the rate and nature of infection in a cohort of children with SLE. METHODS Records of 70 children with SLE were reviewed for documentation of infections. All patients with infection seen between 1990 and 1998 were included. Data extracted comprised demographics and clinical features including the disease activity index (SLEDAI), detailed descriptions of therapy, and res...

In juvenile onset systemic lupus erythematosus (SLE), musculoskeletal involvement is one of the most common manifestations. Musculoskeletal symptoms may be due to disease activity itself, organ damage SLE activity, drug exposure, or comorbidities. Although they are not life-threatening, still have a significant impact on disability severity and social exclusion. This article discusses clinical ...

Introduction Psychiatric manifestations in juvenile systemic lupus erythematosus (JSLE) are not uncommon, and they often pose diagnostic and therapeutic challenges. Magnetic resonance imaging (MRI) of the brain is often without abnormalities. Fluorodeoxyglucose positron emission tomography (FDG PET) detects relative reductions in regional cerebral glucose metabolism, and has been suggested as a...