Objective: The loading of drugs into mesoporous silica (MS) is an effective strategy to improve the solubility poorly water-soluble drugs. Previous reports have stated that surface area and pore volume MS can affect drug its crystallization in MS. Therefore, this study aims elucidate effect size on maximum dissolution profile. Methods: ritonavir (RTV) itraconazole (ITZ) were encapsulated-MS usi...

Paecilomyces variotii was isolated from two subsequent cerebrospinal fluid (CSF) specimens of a cancer patient. Identification was confirmed through beta-tubulin and rDNA ITS sequencing. MICs were determined for seven antifungal agents; the isolate was found to be susceptible to amphotericin B (AMB), itraconazole (ITZ), ketaconazole (KTZ) and 5-fluorocytosine (5FC) but resistant to fluconazole ...

Paracoccidioidomycosis (PCM) is a primary pulmonary infection that often disseminates to other organs and systems. Involvement of the central nervous system (CNS) is rare and due to the fact that both clinical alertness and establishment of the diagnosis are delayed, the disease progresses causing serious problems. We report here a case of neuroparacoccidioidomycosis (NPCM), observed in a 55 ye...

Sporothrix schenckii was reclassified as a complex encompassing six cryptic species, which calls for the reassessment of clinical and epidemiological data of these new species. We evaluated the susceptibility of Sporothrix albicans(n = 1) , S. brasiliensis(n = 6) , S. globosa(n = 1), S. mexicana(n = 1) and S. schenckii(n = 36) to terbinafine (TRB) alone and in combination with itraconazole (ITZ...

An experimental model of murine chromoblastomycosis and in vitro tests with Fonsecaea pedrosoi were used to test the sensitivity of this fungus to three different antimycotics. The experimental model was standardized in BALB/c mice inoculated intraperitoneally with a 10(6) CFU/ml suspension of a F. pedrosoi isolate. Clinical infection was evident after 5 days of inoculation. Three groups of 27 ...

Nanomechanical Properties of Cementitious Materials Paramita Mondal Although cementitious construction materials are mainly used in a large scale and in huge quantities, fundamental properties such as strength, ductility, creep, shrinkage, and fracture behavior depend, to a great extent, on structural elements and phenomena which are effective at the microand nanoscale. This research involves c...

The intertidal zone (ITZ) is a highly dynamic and diverse coastal ecosystem under pressure that provides important eco-services. Being periodically water makes it challenging to monitor, the only possibility map in all tidal stages by using dense time series of observations. At high latitudes, Sentinel-1 (S1) constellation European Copernicus Program consistently radar imagery at fixed times on...