A transdermal dosage form of trazodone hydrochloride (TZN) may be useful in the treatment of moderate to severe depression in schizophrenic patients by providing prolonged duration of action. It will also improve patient compliance and bioavailability. Controlled input of TZN would attenuate fluctuating plasma level of TZN resulting from oral therapy. The aim of the current investigation was to...

Aim: Different promising colloidal delivery systems including microemulsions and liquid crystals could be obtained with suitable combination of oil, surfactants/cosurfactants and water. However, the main problem from a formulation point of view has been to choose the surfactants capable of forming such systems and be physiologically acceptable in the same time. To overcome the later shortcoming...

The release kinetics of dihydroetorphine (DHE) from pressure-sensitive adhesive (PSA) tape with an ethylene-vinyl acetate co-polymer (EVA) membrane as a diffusion-controlling membrane and its protective effect from an unpredictable increase in skin permeation of DHE caused by stratum corneum damage were investigated. The DHE flux through the EVA membrane was enhanced with the increase of vinyl ...

OBJECTIVE To deliver 2,3,5,6-tetramethylpyrazine (TMP) in a relatively large dose through a transdermal route and facilitate the practical application of microemulison in transdermal drug delivery. METHODS The pseudo-ternary phase diagram for microemulsion regions was constructed using isopropyl myristate as oil phase, Labrasol(®) as surfactant, and Plurol(®) Oleique CC 497 as cosurfactant. A...

Chrysin is a bioactive flavonoid found in pollens, passion flowers, honey, royal jelly, and propolis, which commonly used as an ingredient natural food supplements primarily responsible for their pharmacological properties. A transparent chrysin-loaded microemulsion (CS-ME) prepared through ternary phase diagram was evaluated use antihyperalgesic formulation. It formulated with 40% Labrasol® (s...

Objective: To develop coenzyme Q10 (co-Q10) nanostructured lipid carriers (NLCs) using stearic acid (SA) and various liquid lipids with different lipophilicity as well highlights the use of in silico studies for predicting elucidating interaction drug-lipid used carries NLCs, at molecular level.
 Methods: The co-Q10 NLCs were prepared SA solid oleic (OA), isopropyl myristate (IPM), palmita...

To initiate our research into the development of biocompatiîle gelled-microemulsions based on essential oils (EOs) and sucrose esters (SEs) for topical delivery fluconazole, this formulation study investigated usefulness two relatively harmless natural non-ionic surfactants from group SEs (sucrose laurate stearate) to form, in presence antifungal EOs, stable, isotropic microemulsions effective ...

Two different types of soft alkyl ether prodrugs incorporating ethyleneoxy groups into the promoiety have been synthesized for a model phenol (acetaminophen, APAP): alkyloxycarbonyloxymethyl type (AOCOM) and N-alkyl-N-alkyloxycarbonyl-aminomethyl type (NANAOCAM). The solubilities in isopropyl myristate, S(IPM), and water, S(AQ), partition coefficients between IPM and pH 4.0 buffer, K(IPM:4.0), ...